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https://doi.org/10.14300/mnnc.2020.15136

Effect of neuroleptics chronic administration on the content of protein s100 in blood and the level of autoantibodies to it in rats

[Experimental medicine]
Mariya Baturina; Eduard Beyer; Sergey Alexandrovich Zhurbin; Arevik Arkadyevna Fil;

Long-term haloperidol administration leads to an increase in the level of S100 protein in the blood plasma of rats, regardless of the dose of drugs used (0.1 and 0.5 mg/kg). The use of risperidone 0.5 mg/kg (no more 0.1 mg/kg) also increased S100 protein level in the blood. The S100 level did not change with the risperidone 0.1 mg/kg administration. Simultaneously, the substances in both doses increased the level of autoantibodies to the S100 protein. This effect was most pronounced with the administration of a high dose of risperidone.

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References:
1. Wong D., Adams C. E., David A., Quraishi S. N. Depot bromperidol decanoate for schizophrenia. Cochrane Database Systematic Reviews. 2004;(3):CD001719. https://doi.org/10.1002/14651858.CD001719.pub2
2. Arushanyan E. B. Psihofarmakologiya. Stavropol’, «StGMA», 2008. (In Russ.).
3. Kasahara R., Yamamoto N., Suzuki K., Sobue K. The σ1 receptor regulates accumulation of GM1 gangliosideenriched autophagosomes in astrocytes. Neuroscience. 2017;340:176-187. https://doi.org/10.1016/j.neuroscience.2016.10.058
4. Arushanian E. B. Participation of neuroglia in pathogenesis of schizophrenia and antipsychotic drug effect. Eksperimental’naya i klinicheskaya farmakologiya. – Experimental and Clinical Pharmacology. 2019;82(1):30-34. (In Russ.). https://doi.org/10.30906/0869-2092-2019-82-1-30-34
5. Bankston A. N., Mandler M. D., Feng Y. Oligodendroglia and neurotrophic factors in neurodegeneration. Neuroscience Bulletin. 2013;29(2):216-228. https://doi.org/10.1007/s12264-013-1321-3
6. Domingues A. V., Pereira I. M., Vilaça-Faria H., Salgado A. J., Rodrigues A. J., Teixeira F. G. Glial cells in Parkinson ´s disease: protective or deleterious? Cellular and Molecular Life Sciences: CMLS. 2020;77(24):5171-5188. https://doi.org/10.1007/s00018-020-03584-x
7. Gonzalez L. L., Garrie K., Turner M. D. Role of S100 proteins in health and disease. Biochimica et Biophysica Acta. Molecular cell Research. 2020;1867(6):118677. https://doi.org/10.1016/j.bbamcr.2020.118677
8. Kozlyuk N., Monteith A. J., Garcia V., Damo S. M., Skaar E. P., Chazin W. J. S100 Proteins in the Innate Immune Response to Pathogens. Methods in Molecular Biology. 2019;1929:275-290. https://doi.org/10.1007/978-1-4939-9030-6_18
9. Andreassen О. А., Jørgensen H. A. Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats. Implications for tardive dyskinesia? Progress in Neurobiology. 2000;61(5):525-541. https://doi.org/10.1016/s0301-0082(99)00064-7
10. Sacchi S., De Novellis V., Paolone G. Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity. Scientific Reports. 2017;10(7):46288. https://doi.org/10.1038/srep46288
11. Singh S. P., Singh V. Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 2011;25(10):859-885. https://doi.org/10.2165/11586650-000000000-00000
12. Baturina M. V., Beier E. V., Baturin V. A. Popov A. V. Dependence of the severity of haloperidol catalepsy on the activity of dopaminergic and glutamatergic systems of the brain of rats with prolonged use of antipsychotics. Medicinskii vestnik Severnogo Kavkaza. –Medical News of North Caucasus. 2020;15:307-310. (In Russ.). https://doi.org/10.14300/mnnc.2020.15073
13. Isom A. M., Gudelsky G. A., Benoit S. B. Antipsychotic medications, gluta-mate, and cell death: a hidden, but common medication side effect? Medical Hypotheses. 2013;80(3):252-258. https://doi.org/10.1016/j.mehy.2012.11.042
14. Samad N., Haleem D. J. Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats. Metabolic Brain Disease. 2017;32(4):1099-1107. https://doi.org/10.1007/s11011-017-0002-8
15. Raudenska M., Gumulec J., Babula P. Haloperidol cytotoxicity and its relation to oxidative stress. Mini Reviews in Medicinal Chemistry. 2013;13(14):1993-1998. https://doi.org/10.2174/13895575113136660100
16. Dejanović B., Vuković-Dejanović V., Stevanović I., Mandić-Gajić G., Dilber S. Oxidative stress induced by chlorpromazine in patients treated and acutely poisoned with the drug. Vojnosanitetski Pregled. 2017;73(4):312-327. https://doi.org/10.2298/VSP140423047D
17. Levite M. Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases. Acta Physiology (Oxf). 2016;216(1):42-89. https://doi.org/10.1111/apha.12476

Keywords: haloperidol, risperidone, S100 protein, autoantibodies