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https://doi.org/10.14300/mnnc.2020.15135

Effect of melatonin on reparative regeneration of bone tissue in the jaw bones experiment

[Experimental medicine]
Evgeny Shchetinin; Ekaterina Sergeevna Sirak; Galina Aleksandrovna Afanaseva; Gregory Petrosyan; Elizaveta Evgenievna Shchetinina; Sergey Sirak;

The article presents the results of studying the effect of melatonin on osteogenesis in the formation of a standardized defect in the lower jaw of Guinea pigs: a hole with a diameter of 5 mm. The optimizing effect of chronic use of melatonin at a dose of 5 mg/kg on the processes of remodeling in the jawbones, mainly at the early stages of osteogenesis by increasing bone mass, including by suppressing bone resorption, and activating osteoblast differentiation, was revealed.

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Keywords: osteogenesis, bone defect, melatonin, experiment