• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2020.15133

Use of natural products for correction of abdominal obesity in experimental metabolic syndrome

[Experimental medicine]
Anatoly Vladimirovich Kubyshkin; Yulianna Ivanovna Shramko; Evgeniya Yurievna Zyablitskaya; Vitalina Igorevna Petrenko; Nikolay Alexandrovich Ivashchenko; Kirill Olegovich Karimov; Inna V. Chernousova; Yuri Alekseevich Ogay;

An experimental study was carried out on 30 white male rats using the fructose model of metabolic syndrome (MS). For 12 weeks, animals from the experimental group (n=10) received in addition to the diet the polyphenolic product of grape processing «Fanocor». It was found that the size of adipocytes of abdominal fatty tissue in animals with metabolic syndrome (MS) exceeded those in the control group by 2.1 times (p<0.05). The size distribution curve of adipocytes in MS was characterized by significant variability and a shift towards a general increase in size. The MS correction with the «Fanocor» resulted in a decrease of fat cells size by 2.5 times (p<0.05) compared with the group with MS without correction; the variation became moderate, and the size of most of the cells was below average in the control group. A significant decrease in the size of adipocytes caused by the polyphenolic product of grape processing «Fanokor» assumes clinical trials of grape polyphenols for the prevention of obesity.

Download

References:
1. NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants. The Lancet. 2016;387:1377-1396. https://doi.org/10.1016/S0140-6736(16)30054-X
2. Balkau B., Valensi P., Eschwege E., Slama G. A review of the metabolic syndrome. Diabetes & Metabolism. 2007;33:405-413. https://doi.org/10.1016/j.diabet.2007.08.001
3. Boronat M., Saavedra P., Varillas V. F., Wagner A. M., López-Plasencia Y. [et al.]. Differences in traditional and emerging cardiovascular risk factors of subjects discordantly classifi ed by metabolic syndrome defi nitions of the International Diabetes Federation and the National Cholesterol Education Program. Nutr. Metab. Cardiovasc. Dis. 2009;19(6):417-422. https://doi.org/10.1016/j.numecd.2008.07.010
4. Stolarczyk E. Adipose tissue infl ammation in obesity: a metabolic or immune response? Curr. Opin. Pharmacol. 2017;37:35-40. https://doi.org/10.1016/j.coph.2017.08.006
5. Asghar A., Sheikh N. Role of immune cells in obesity induced low grade infl ammation and insulin resistance. Cell. Immunol. 2017;315:18-26. https://doi.org/10.1016/j.cellimm.2017.03.001
6. Cao H. Obesity and obesity-induced disorders: from molecular mechanisms to promising therapeutic targets. Drug Discovery Today: Disease Mechanisms. 2013;10(1-2):e1-e3. https://doi.org/10.1016/j.ddmec.2013.06.001
7. Fang H., Judd R. L. Adiponectin Regulation and Function. Comprehensive Physiology. 2018;8(3):1031-1063. https://doi.org/10.1002/cphy.c170046
8. Kucherenko A. S., Petrenko V. I., Kubyshkin A. V., Fomochkina I. I., Sorokina L. E. [et al.]. Study of mechanisms of neurodegenerative processes in experimental modeling of metabolic syndrome. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2019;14(1):211-216. (In Russ.). https://doi.org/10.14300/mnnc.2019.14017
9. Makarova M. N., Makarov V. G. Diet-induced models of metabolic disorders. Experimental metabolic syndrome. Laboratornye zhivotnye dlya nauchnych issledovanii. –Laborat. Animals Sci. 2018;(1):79-91. (In Russ.). https://doi.org/10.29296/2618723x-2018-01-08
10. Collins T. J. Image J for microscopy. Biotechniques. 2007;43(1):25-30. https://doi.org/10.2144/000112517
11. Stenkula K. G., Erlanson-Albertsson C. Adipose cell size: importance in health and disease. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2018;315(2):284-295. https://doi.org/10.1152/ajpregu.00257.2017
12. Yang J., Eliasson B., Smith U., Cushman S. W., Sherman A. S. The size of large adipose cells is a predictor of insulin resistance in fi rst-degree relatives of type 2 diabetic patients. Obesity. 2012;20(5):932-938. https://doi.org/10.1038/oby.2011.371
13. Engin A. Adiponectin-Resistance in Obesity. Adv. Exp. Med. Biol. 2017;960:415-441. https://doi.org/10.1007/978-3-319-48382-5_18

Keywords: polyphenolic products of grape processing, metabolic syndrome, abdominal obesity