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https://doi.org/10.14300/mnnc.2013.08004

Calcium homeostasis in patients with osteoarthritis

[Original research] [Internal diseases]
Vitaly Obydenkov; Igor Totrov; Zara Khetagurova;

The study of calcium homeostasis in 120 patients
with primary OA showed an increase in PTH levels in
these patients.
High (p<0.01) content of parathyroid hormone
in total group of OA patients compared to the
control group (53,36±1,06 pg/ml 46,47±2,36 pg/ml
respectively) was determined significantly.
In the group of OA patients with gonarthrosis
manifestations PTH content was significantly
elevated in comparison with the CG (p<0,01). In OA
patients with coxofemoral joint lesions a significant
increase of PTH (p<0,05) in comparison with the
control group was also found.
Apparently, this is the cause of cartilage
calcification and alters its elasticity, which leads to
its destruction.
In OA patients normal Ca2 + concentration in
blood at elevated PTH levels in blood serum was
revealed.
Disturbance of calcium homeostasis in patients
with osteoarthritis is connected with the action of
parathyroid hormone, which, being a regulator of
calcium metabolism, increases compensatory.
Disturbance of calcium homeostasis in patients
with osteoarthritis leads to calcification of cartilage
that causes a disturbance of its functions. Cartilage
micro-traumas aggravate its condition and lead to
the progression of the disease.

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Keywords: osteoarthritis, parathyroid hormone, hyperparathyroidism