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Comparative characteristics of the expression of immunohistochemical markers of proliferation at various degrees of cervical dysplasia

[Obstetrios and gynecology]
Tatiana Alexandrovna Dimitriadi; Dmitry Burtsev; Elena Alekseevna Jenkova; Tatiana Nikolaevna Gudtskova; Konstantin Vladimirovich Dvadnenko;

The expression of proliferation markers (Ki-67, CyclinD1, p16INK4a) in healthy tissue of the cervix, cervical intraepithelial neoplasias of grades 1–3 and carcinoma in situ in 110 HPV-positive women was studied immunohistochemically. It was noted that the severity of expression of proliferation markers was associated with the severity of dysplastic changes in the cervical tissue. The established quantitative values of markers for each variant of neoplasia are an additional tool for screening and clarifying the diagnosis in this group of patients.


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Keywords: cervix, dysplasia, immunohistochemical analysis, proliferation marker, Ki-67, p16INK4a, Cyclin D1

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy