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Influence of urokinase gene knockout in C57BL/6-Plautmi.IBug-This Plau6FDhu/GFDhu mice on levels of brain neurotrophin receptors in experimental melanoma developing in presence of chronic neurogenic pain

[Experimental medicine]
Elena Frantsiyants; Valeriya Bandovkina; Irina Kaplieva; Irina Valerievna Neskubina; Ekaterina Igorevna Surikova; Natalia Cheryarina; Lydia Trepitaki; Natalya Sergeevna Lesovaya;

The results of assessing the dynamics of the content of estrogen receptors (ER-α and β), androgens (RA) and progesterone (RP4) in the brain of mice of the C57BL/6 and C57BL/6-PlautmI.IBug-This Plau6FDhu/GFDhu lines knocked out by the urokinase gene, with the growth of experimental melanoma B16/F10 in an independent variant and associated with chronic neurogenic pain (CNP) in 80 mice are presented. The level of neurosteroid receptors in the brain is probably related to tumor volume. A sharp increase in the volume of tumors in urokinase knockout mice under the influence of CNP was accompanied by a decrease in the ER-α+ER-β/RA ratio in the brain as compared with the indices in knockout mice with spontaneous melanoma growth. In C57Bl/6 females, CNP had no significant effect on tumor volumes and the ER-α+ER-β/RA ratio.


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Keywords: urokinase gene-knockout mice, chronic neurogenic pain, В16/F10 melanoma, neurosteroid receptors

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
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