310 Mira Street, Stavropol, Russia, 355017
+7 865 2352511, +7 865 2353229.
The journal is included into The list of leading scientific periodicals.
A study to create an experimental model of acute dynamic intestinal obstruction using the pharmacological effects of Loperamide was carried out on 36 male Wistar rats. All animals were divided into 3 groups. Loperamide was administered 2 times a day at 12-hour intervals for 5 days at a daily dose of 0.022 mg/kg, 0.044 mg/kg or 0.09 mg/kg. The results were assessed by the number of defecations, macro- and microscopic picture, morphometric data. As a result of morphological studies in the first and second groups, macroscopic, histological and morphometric changes in the wall of the small intestine during the study period did not differ significantly from normal values. The model of compensated dynamic intestinal obstruction was achieved in the third group of animals (0.09 mg/kg/day) 72 hours after the start of the experiment. 120 hours after the start of the experiment, the animals formed a model of decompensated dynamic intestinal obstruction with characteristic macro- and microscopic changes in the intestine
1. Griffiths Sh., Glancy D. G. Intestinal obstruction. Surgery. 2020;38(1);43-50.
2. Rami Reddy S. R., Cappell M. S. A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction. Current Gastroenterology Reports. 2017;19(6):28. https://doi.org/10.1007/s11894-017-0566-9
3. Paulson E. K., Thompson W. M. Review of Small-Bowel Obstruction: The Diagnosis and When to Worry. Radiology. 2015;275(2):332-342. https://doi.org/10.1148/radiol.15131519
4. Reddy R., Ravinder N. A Study on Intestinal Obstruction. Annals of International Medical and Dental Research. 2019;5(3):SG45-SG46. https://doi.org/10.21276/aimdr.2019.5.3.SG12
5. Sheyn D., Bretschneider C. E., Mahajan S. T., Ridgeway B., Davenport A., Pollard R. Incidence and risk factors of early postoperative small bowel obstruction in patients undergoing hysterectomy for benign indications. American Journal of Obstetrics & Gynecology. 2019;220(3):251. https://doi.org/10.1016/j.ajog.2018.11.1095
6. Leite Jr. R., Mello N. B., Pereira L. P. M., Takiya C. M., Oliveira A. B., Schanaider A. Enterocyte ultrastructural alterations following intestinal obstruction in rats. Acta Cirurgica Brasileira. 2010;25(1):2-8. https://doi.org/10.1590/s0102-86502010000100003
7. Li L., Zou C., Zhou Z., Wang X., Yu X. Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model. Brazilian Journal of Medical and Biological Research. 2019;52(10):e8343. https://doi.org/10.1590/1414-431X20198343
8. Amanova D. E., Koyshibaev Zh. M., Akhmaltdinova L. L., Matyushko D. N., Turgunov E. M. The dynamics of levels of lypopolysaccharide-binding protein and procalcitonin during the experimental acute intestinal o bstruction. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2019;14(1):145-148. (In Russ.). https://doi.org/10.14300/mnnc.2019.14001
9. van Bree S. H., Nemethova A., van Bovenkamp F. S., Gomez-Pinilla P., Elbers L. [et al.]. Novel method for studying postoperative ileus in mice. International Journal Physiology Pathophysiology Pharmacology. 2012;4(4):219-227.
Keywords: dynamic intestinal obstruction, ileus paralytic, morphometric analysis, intestinal pathomorphology