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of the North Caucasus
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ISSN 2073-8137

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Influence of load on modeling and remodeling of bone tissue in experimental perimplantitis

[Experimental medicine]
Sergey Sirak; Maria Olegovna Didenko; Alla Sirak; Elizaveta Evgenievna Shchetinina; Ekaterina Sergeevna Sirak; Alina Vladimirovna Pogozheva; Gregory Petrosyan; Vadim Nikolaevich Lenev;

The article presents the results of a study of the features of osseointegration of dental implants in experimental perimplantitis, in which perimplant defects of the jaw healed in the control group under a blood clot, and were filled with a mixture of calcium hydroxyapatite and tricalcium phosphate modified with hyaluronic acid in the main group. The aim of the study was to assess the intensity of reparative bone regeneration in the perimplant zone in static and with chewing loads. As a result of the study, it was found that early functional loads on dental implants do not contribute to acceleration of the processes of modeling and remodeling of bone tissue in perimplantitis, and the use of osteoplastic material based on calcium sulfate modified with hyaluronic acid is comparable in effectiveness with reparative bone regeneration in the perimplant zone during natural healing of a wound under a blood clot, providing active autogenous neovasculogenesis due to hematopoietic stem cells in the early period (1–3 months).


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Keywords: modeling, remodeling, bone tissue, jaw, experiment, perimplantitis

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy