logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Long-term consequences in the offspring born by rats with experimental preeclampsia

[Experimental medicine]
Elena Andreevna Muzyko; Valentina Nikolaevna Perfilova; Margarita Valerievna Kustova; Kirill Vitalievich Suvorin; Ivan Nikolaevich Tyurenkov; Vladimir Ivanovich Petrov;

The offspring of rats with experimental preeclampsia modeled by replacing drinking water with a 1.8 % sodium chloride solution from 1 to 21 days of gestation had cognitive dysfunction, which manifests itself in a deterioration in learning and memory at the age of 25 months. At 27 months in animals born to females with complicated pregnancy, disorders of carbohydrate and lipid metabolism, renal excretory function were revealed.

Download

References:
1. Phipps E. A., Thadhani R., Benzing T., Karumanchi S. A. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nature Reviews Nephrology. 2019;15(5):275-289. https://doi.org/10.1038/s41581-019-0119-6
2. Stojanovska V., Scherjon S. A., Plösch T. Preeclampsia as modulator of offspring health. Biology of Reproduction. 2016;94(3):53. https://doi.org/10.1095/biolreprod.115.135780
3. Dachew B. A., Mamun A., Maravilla J. C., Alati R. Association between hypertensive disorders of pregnancy and the development of offspring mental and behavioural problems: a systematic review and meta-analysis. Psychiatry Research. 2018;260:458-467. https://doi.org/10.1016/j.psychres.2017.12.027
4. Maher G. M., McCarthy F. P., McCarthy C. M., Kenny L. C., Kearney P. M. [et al.]. A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: Does maternal inflammation play a role? International Journal of Developmental Neuroscience. 2019;77:69-76. https://doi.org/10.1016/j.ijdevneu.2018.10.004
5. Sacks K. N., Friger M., Shoham-Vardi I., Spiegel E., Sergienko R. [et al.]. Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring. Pregnancy Hypertension. 2018;13:181-186. https://doi.org/10.1016/j.preghy.2018.06.013
6. Rosenfeld C. S., Ferguson S. A. Barnes maze testing strategies with small and large rodent models. JoVE Journal. 2014;(84):e51194. https://doi.org/10.3791/51194
7. Dang F., Croy B. A., Stroman P. W., Figueiró-Filho E. A. Impacts of Preeclampsia on the Brain of the Offspring. Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(8):416-422. https://doi.org/10.1055/s-0036-1584515
8. Rätsep M. T., Hickman A. F., Croy B. A. The Elsevier trophoblast research award lecture: impacts of placental growth factor and preeclampsia on brain development, behaviour, and cognition. Placenta. 2016;48(Suppl. 1):S40-S46. https://doi.org/10.1016/j.placenta.2016.02.001
9. Timpka S., Macdonald-Wallis C., Hughes A. D., Chaturvedi N., Franks P. W. [et al.]. Hypertensive disorders of pregnancy and offspring cardiac structure and function in adolescence. Journal of the American Heart Association. 2016;5(11):e003906. https://doi.org/10.1161/JAHA.116.003906
10. Plank C., Ostreicher I., Hartner A., Marek I., Struwe F. G. [et al.]. Intrauterine growth retardation aggravates the course of acute mesangioproliferative glomerulonephritis in the rat. Kidney International. 2006;70(11):1974-1982. https://doi.org/10.1038/sj.ki.5001966
11. Herrera-Garcia G., Contag S. Maternal Preeclampsia and Risk for Cardiovascular Disease in Offspring. Current Hypertension Reports. 2014;16(9):475. https://doi.org/10.1007/s11906-014-0475-3
12. Akhaphong B., Lockridge A., Jo S., Mohan R., Wilcox J. A. [et al.]. Reduced uterine perfusion pressure causes loss of pancreatic β-cell area but normal function in fetal rat offspring. American Journal of Physiology –Regulatory, Integrative and Comparative Physiology. 2018;315(6):R1220-R1231. https://doi.org/10.1152/ajpregu.00458.2017
13. Peixoto A. B., Rolo L. C., Nardozza L., Araujo Júnior E. Epigenetics and Preeclampsia: Programming of Future Outcomes. Methods in Molecular Biology. 2018;1710:73-83. https://doi.org/10.1007/978-1-4939-7498-6_6
14. Yu Y. C., Jiang Y., Yang M. M., He S. N., Xi X. [et al.]. Hypermethylation of delta-like homolog 1/maternally expressed gene 3 loci in human umbilical veins: Insights into offspring vascular dysfunction born after preeclampsia. Journal of Hypertension. 2019;37(3):581-589. https://doi.org/10.1097/HJH.0000000000001942

Keywords: experimental preeclampsia, offspring, long-term consequences


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy