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https://doi.org/10.14300/mnnc.2020.15084

Long-term consequences in the offspring born by rats with experimental preeclampsia

[Experimental medicine]
Elena Andreevna Muzyko; Valentina Nikolaevna Perfilova; Margarita Valerievna Kustova; Kirill Vitalievich Suvorin; Ivan Nikolaevich Tyurenkov; Vladimir Ivanovich Petrov;

The offspring of rats with experimental preeclampsia modeled by replacing drinking water with a 1.8 % sodium chloride solution from 1 to 21 days of gestation had cognitive dysfunction, which manifests itself in a deterioration in learning and memory at the age of 25 months. At 27 months in animals born to females with complicated pregnancy, disorders of carbohydrate and lipid metabolism, renal excretory function were revealed.

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Keywords: experimental preeclampsia, offspring, long-term consequences