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ISSN 2073-8137

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Experimental substantiation of mesenchymal stem cell application for the restoration of periodontal tissue

[Experimental medicine]
Yuliya Denisova; Sergey Sirak; Sergey Rubnikovich; Vasilina Anatolyevna Andreeva; Elena Viktorovna Kuzmenko; Ilya Stanislavovich Khomich; Igor Dmitrievich Volotovsky; Tatiana Ernstovna Vladimirskaya;

The article presents the results of the development of a model of experimental periodontitis and analysis of morphological changes in periodontal tissues in experimental animals using mesenchymal stem cells of adipose tissue (MSCs AT). As confirmed by morphological characteristics of newly formed bone tissue the restorative process in periodontal tissues was most pronounced in experimental groups of animals where collagen membranes with a suspension of cultures of allogeneic osteoinduced MSCs AT and collagen membranes with a mixture of cultures of allogeneic MSCs AT and allogeneic osteoinduced MSCs AT in a ratio 1:1 were applied.


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Keywords: mesenchymal stem cells, periodontitis, bone regeneration

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy