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Prediction of the course of diverticular disease in its combination with adenomatous polyps and colorectal cancer in the context of clinical and instrumental data and expression of Ki-67 and α-SMA in the intestinal mucosa

Mikhail Osadchuk; Andrey Svistunov; Alexandra Zolotovitskaya; Vladimir Reshetnikov; Vasiliy Kozlov; Ekaterina Dmitrievna Mironova; Ekaterina Sergeevna Ogibenina;

The role of clinical and instrumental data, the expression of Ki-67 and α-smooth muscle actin (α-SMA) in the mucous membrane of the large intestine in patients with diverticular disease of the large intestine (DDLI) and its combination with adenomatous intestinal polyps (AIP) and colorectal cancer (CRC) was studied. The study included 190 patients with DDLI (120 people; group 1), when combined with AIP (55 patients; group 2) and with CRC (15 patients; group 3). The control group was represented by 28 patients with irritable bowel syndrome (IBS; group 4). DDLI was verified in the presence of three or more diverticula in the mucous membrane of the colon (MMC). It was found that the expression of Ki-67 in the DDLI group and when combined with AIP and CRC is higher than the average in the group of patients with IBS. The expression of α-SMA in MMC increased in patients with DDLI and reached a maximum in CRC.


1. Nikberg M., Ji J., Leppert J., Sundquist K., Chabok A. Socioeconomic characteristics and comorbidities of diverticular disease in Sweden 1997-2012. Int. J. Colorectal. Dis. 2017;32(11):1591-1596. https://doi.org/10.1007/s00384-017-2853-1
2. Bharucha A. E., Parthasarathy G., Ditah I. [et al.]. Temporal Trends in the Incidence and Natural History of Diverticulitis: A Population-Based Study. Am. J. Gastroenterol. 2015;110(11):1589-1596. https://doi.org/10.1038/ajg.2015.302
3. Everhart J. E. The burden of digestive diseases in the United States. US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Washington, DC: US Government Printing Office, 2008; NIH Publication № 09-6443. Available at: https://www.niddk.nih.gov/about-niddk/strategic-plans-reports/burden-of-digestive-diseases-in-united-states/burden-of-digestive-diseases-in-the-united-states-report. Accessed November 1, 2019.
4. Osipenko M. F., Bikbulatova E. А. Colonic diverticula: origin, prevalence, clinical manifestations. Terapevticheskij arhiv. – Therapeutic Archive. 2007;(2):26-31 (In Russ.).
5. Jaruvongvanich V., Sanguankeo A., Wijarnpreecha K., Upala S. Risk of colorectal adenomas, advanced adenomas and cancer in patients with colonic diverticular disease: Systematic review and meta-analysis. Dig. Endosc. 2017;29(1):73-82. https://doi.org/10.1111/den.12701
6. Meurs-Szojda M. M., Terhaar sive Droste J. S., Kuik D. J., Mulder C. J. J., Felt-Bersma R. J. F. Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies. Int. J. Colorectal. Dis. 2008;23(10):979-984. https://doi.org/10.1007/s00384-008-0510-4
7. Urruticoechea A., Smith I. E., Dowsett M. Proliferation marker Ki-67 in early breast cancer. J. Clin. Oncol. 2005;23(28):7212-7220. https://doi.org/10.1200/JCO.2005.07.501
8. Paik S., Shak S., Tang G. [et al.]. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 2004;351(27):2817-2826. https://doi.org/10.1056/NEJMoa041588
9. Cidado J., Wong H. Y., Rosen D. M. [et al.]. Ki-67 is required for maintenance of cancer stem cells but not cell proliferation. Oncotarget. 2016;7(5):6281-6293. https://doi.org/10.18632/oncotarget.7057
10. Strate L. L., Modi R., Cohen E., Spiegel B. M. R. Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. Am. J. Gastroenterol. 2012;107(10):1486-1493. https://doi.org/10.1038/ajg.2012.194
11. Spiller R. Editorial: new thoughts on the association between diverticulosis and irritable bowel syndrome. Am. J .Gastroenterol. 2014;109(12):1906-1908. https://doi.org/10.1038/ajg.2014.367
12. Drapkina O. M., Deeva T. А., Ivashkin V. T. Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease. Terapevticheskij arhiv. – Therapeutic Archive. 2015;87(5):76-83. (In Russ.). https://doi.org/10.17116/terarkh201587576-83
13. Juneja M., Kobelt D., Walther W. [et al.]. Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. PLoS Biol. 2017;15(6):e2000784. https://doi.org/10.1371/journal.pbio.2000784
14. Yokomichi H., Nagai A., Hirata M. [et al.]. Statin use and all-cause and cancer mortality: BioBank Japan cohort. J. Epidemiol. 2017;27(3S):S84-S91. https://doi.org/10.1016/j.je.2016.12.011
15. Díaz-Flores L., Gutiérrez R., García M. P. [et al.]. Human resident CD34+ stromal cells/telocytes have progenitor capacity and are a source of αSMA+ cells during repair. Histol. Histopathol. 2015;30(5):615-627. https://doi.org/10.14670/HH-30.615
16. Hawinkels L. J., Paauwe M., Verspaget H. W. [et al.]. Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts. Oncogene. 2014;33(1):97-107. https://doi.org/10.1038/onc.2012.536
17. Valcz G., Sipos F., Krenács T. [et al.]. Increase of α-SMA(+) and CK (+) cells as an early sign of epithelial-mesenchymal transition during colorectal carcinogenesis. Pathol. Oncol. Res. 2012;18(2):371-376. https://doi.org/10.1007/s12253-011-9454-z
18. Hsia L.-T., Ashley N., Ouaret D., Wang L. M., Wilding J., Bodmer W. F. Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers. Proc. Natl. Acad. Sci. USA. 2016;113(15):E2162-2171. https://doi.org/doi:10.1073/pnas.1603534113
19. Pascal R. R., Kaye G. I., Lane N. Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. I. Autoradiographic studies of normal rabbit colon. Gastroenterology. 1968;54(5):835-851.
20. Roberts J. A., Waters L., Ro J. Y., Zhai Q. J. Smoothelin and caldesmon are reliable markers for distinguishing muscularis propria from desmoplasia: a critical distinction for accurate staging colorectal adenocarcinoma. Int. J. Clin. Exp. Pathol. 2014;7(2):792-796.

Keywords: diverticular diseases, adenomatous polyposis of the colon, colorectal cancer, Ki-67, α-SMA

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Pyatigorsk State Research Institute of Balneotherapeutics
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