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https://doi.org/10.14300/mnnc.2019.14125

Congenital infections and congenital malformation in children

[Pediatrics]
Lyudmila Barycheva; Marina Golubeva; Elena Nikolaevna Rakitina; Ekaterina Sergeevna Kuzmina;

A retrospective analysis of the results of observation of young children with intrauterine infections and congenital malformations was carried out. In 127 cases, congenital cytomegalovirus infection diagnosed in children with congenital malformations, congenital toxoplasmosis in 69. It revealed that children with developmental defects with congenital cytomegalovirus infection have higher mortality rates (61 %) than with congenital toxoplasmosis (35 %). In children with congenital cytomegaly prevails an embryopathy. In children with congenital toxoplasmosis dominate a fetopathy. Deceased children with congenital cytomegalovirus infection more often than with congenital toxoplasmosis develop defects of internal organs (congenital heart disease, anomalies of the gastrointestinal tract and urinary tract, pneumopathy). Congenital toxoplasmosis in the section dominated by fetopathies of the central nervous system and the eye. In surviving children with congenital toxoplasmosis, severe disabling effects of central nervous system lesions and eyes in the form of occlusive hydrocephalus, cerebral palsy, complete or partial blindness, cerebro-asthenic disorders are formed more often than with cytomegalovirus infection.

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Keywords: congenital cytomegalovirus infection, congenital toxoplasmosis, congenital malformations, outcomes, children