Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


The effect of oxidative stress on semen quality. Pathogenetic aspects

Nikolai Vladimirovich Sturov; Nataliya Rudolfovna Pashina; Sergej Mihajlovich Ryzhakin; Elina Arkad’evna Korovyakova; Natal’ya Vladimirovna Karaseva; Sergey Pashin; Aleksandr Alekseevich Barkhudarov; Nadezhda Konstantinovna Druzhinina;

It is known that one of the main pathogenetic mechanisms of male infertility is increasing the level of reactive oxygen species (ROS) in the ejaculate. Thereby identify of pathogenetic factors of oxidative stress in pathospermia is very actually. A retrospective analysis of 230 men with poor semen quality (according to criteria of semen, WHO 2010) and increased ROS in the native ejaculate was conducted. The highest amount of ROS in infertile men was in combination with varicocele and chronic prostatitis category 2. ROS level was significantly higher (p<0.05) in men using a mobile phone compared to patients with bad habits (alcohol use). Thus identify the pathogenesis of ROS formation in the ejaculate to choose the right pathogenetic treatment of male infertility, as well as to use preventive measures to combat pathospermia.


1. Bui A. D., Sharma R., Henkel R., Agarwal A. Reactive oxygen species impact on sperm DNA and its role in male infertility. Andrologia. 2018;50(8):e13012. https://doi.org/10.1111/and.13012
2. Kaprin A. D., Kostin A. A., Kulchenko N. G., Fomin D. K., Aliev A. R. O. Diagnosis of idiopathic infertility. What’s new? Vestnik Rossijskogo nauchnogo centra rentgenoradiologii Minzdrava Rossii. 2014;2:3.
3. Fijak M., Pilatz A., Hedger M. P., Nicolas N., Bhushan S. [et al.] Infectious, infl ammatory and ‘autoimmune’ male factor infertility: How do rodent models inform clinical practice? Human Reproduction Update. 2018;24(4):416-441.
4. Kulchenko N. G. Prediction of success in assisted reproductive technology with the help of morphology of the testis. Research’n Practical Medicine Journal. 2018;5(4):18-25.
5. Kourouma A., Peng D., Chao Q., Changjiang L., Chengmin W. [et al.] Bisphenol A induced reactive oxygen species (ROS) in the liver and affect epididymal semen quality in adults Sprague-Dawley rats. Journal of Toxicology and Environmental Health Sciences. 2014;6(4):103-112. https://doi.org/10.5897/JTEHS2014.0309
6. Haidl G., Haidl F., Allam J. P., Schuppe H. C. Therapeutic options in male genital tract inflammation. Andrologia.2019;51(3):e13207. https://doi.org/10.1111/and.13207
7. Kulchenko N. G. Qualitative Criteria for Morphological Evaluation of Spermatogenesis in Azoospermia. Difficult patient. 2018;16(7):48-50.
8. Zandieh Z., Vatannejad A., Doosti M., Zabihzadeh S., Haddadi M. [et al.] Comparing reactive oxygen species and DNA fragmentation in semen samples of unexplained infertile and healthy fertile men. Irish Journal of Medical Science. 2018;187(3):657-662. https://doi.org/10.1007/s11845-017-1708-7
9. Gautam R., Singh K. V., Nirala J., Murmu N. N., Meena R. [et al.] Oxidative stress-mediated alterations on sperm parameters in male Wistar rats exposed to 3G mobile phone radiation. Andrologia. 2019;51(3):e13201. https://doi.org/10.1111/and.13201
10. Kulchenko N. G. Oksidativnyj stress v razvitii neobstruktivnoj azoospermii. Difficult patient. 2017;15(4-5):44-46.
11. Meena R., Kumari K., Kumar J., Rajamani P., Verma H. [et al.] Therapeutic approaches of melatonin in microwave radiations-induced oxidative stress-mediated toxicity on male fertility pattern of Wistar rats. Electromagnetic Biology and Medicine. 2014;33(2),81-91. https://doi.org/10.3109/15368378.2013.781035
12. Kulchenko N. G. Antioxidant therapy for patospermia. Vestnik medicinskogo instituta «REAVIZ»:reabilitaciya, vrach i zdorov’e. 2018;31(1):41-48.
13. Schuppe H. C., Pilatz A., Hossain H., Diemer T., Wagenlehner F. [et al.] Urogenital infection as a risk factor for male infertility. Deutsches Ärzteblatt International. 2017;114:339–346.
14. Adams J. A., Galloway T. S., Mondal D., Esteves S. C., Mathews F. Effect of mobile telephones on sperm quality: A systematic review and meta-analysis. Environment International. 2014;70:106-112.
15. Kulchenko N. G. Inflammation and infertility. What is common? RUDN Journal of Medicine. 2017;21(4):402-407.
16. Ihsan A. U., Khan F. U., Khongorzul P., Ahmad K. A., Naveed M. [et al.] Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress. Biomedicine & Pharmacotherapy. 2018;106:714-723.
17. Gromov A. I., Bujlov V. M. Radiation diagnostics and therapy in urology: national manual. M.: GOEHTAR-Media,2011:544.
18. Kandola K., Bowman A., Birch-Machin M. A. Oxidative stress- a key emerging impact factor in health, ageing, lifestyle and aesthetics. Int. J. Cosmet. Sci. 2015;37(2):1-8.

Keywords: male infertility, oxidative stress, varicocele, chronic prostatitis

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy