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ISSN 2073-8137

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Cytokines of blood serum and amniotic fluid in some complications of pregnancy

Irina Krukier; Valeriya Avrutskaya; Marina Levkovich; Armen Grigoriants; Anastasiya Nikashina; Liana Yerdzhanyan;

128 pregnant women in three groups were examined: 47 women with preterm birth (PB) in the period of 35–37 weeks and 36 women with gestational diabetes mellitus (GDM) were included into 2 main groups. The control group consisted of 45 conditionally healthy women with uncomplicated pregnancy and childbirth. The levels of cytokines: tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), interleukin-1β (IL-1β) and interleukin-10 (IL-10) in serum and amnioticfluid were studied by an enzyme immunoassay.
General patterns and certain features of regulatory reactions in PB and GDM are identified, which gives grounds for the development of diagrams for the diagnosis and treatment of these conditions and will lead to a decrease in perinatal losses.


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Keywords: gestational diabetes mellitus, premature birth, amniotic fluid, blood serum, TNF-α, TGF-β, IL-1β and IL-10

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy