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Peculiarities of endothelial dysfunction in hypertensive patients with additional renal arteries

[Internal diseases]
Natalia Gladkikh; Yulia Redko; Alexandr Yagoda;

The serum levels of endothelin-1 (ET-1) and prostacyclin (PGI2) were assessed in 80 patients with arterial hypertension (AH) and additional renal arteries to determine the endothelial dysfunction. The comparison groups consisted of 15 patients with additional renal arteries without AH and 15 healthy persons. ET-1 and ET-1/PGI2 were increased in all hypertensive patients with additional renal arteries. The severity of endothelial dysfunction in hypertensive patients with additional renal arteries was increased in cases of renal pelvic apparatus doubling and hyperreninemia. Patients with additional renal arteries without hypertension, especially when combined with renal pelvic apparatus doubling, were characterized by increased ET-1 and normal ET/PGI2 that probably reflects the compensation phase of endothelial dysfunction.


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Keywords: endothelial dysfunction, additional renal arteries, arterial hypertension

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy