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https://doi.org/10.14300/mnnc.2019.14033

Aging as a complex of typical pathophysiological processes

[Reviews]
Ilya Solovev; Mikhail Shaposhnikov; Alexey Moskalev; Alexander Viktorovich Melerzanov;

Aging is associated with progressing decline in adaptive abilities in organisms and leads to physiological discoordination of different organs and systems, which negatively influences quality of life and hinders socialization and sanity; at the same time all these factors are connected to the risk of death growth. In the present paper we regard aging as a developing complex of linked changes, realizing via typical pathological processes: inflammation, hypertrophy, dysplasia, apoptosis, necrosis, fibrosis, etc. The suggested approach permits to identify basic pathological processes as targets which might be modified by multiple anti-aging interventions. The review contains the table of pathological processes organized in the connection to systems and organs and the conceptual scheme where the alterative origin of aging processes is shown.

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References:
1. Bulterijs S., Hull R. S., Bjork V. C., Roy A. G. It is time to classify biological aging as a disease. Frontiers of Genetics. 2015;6:205. https://doi.org/10.3389/fgene.2015.00205
2. Anker S. D., Morley J. E., von Haehling S. Welcome to the ICD-10 code for sarcopenia. Journal Cachexia Sarcopenia Muscle. 2016;7(5):512-514. https://doi.org/10.1002/jcsm.12147
3. Franceschi C., Garagnani P., Morsiani C., Conte M., Santoro A. [et al.]. The Continuum of Aging and Age Related Diseases: Common Mechanisms but Different
Rates. Frontiers in Medicine. 2018;5(61). https://doi.org/10.3389/fmed.2018.00061
4. Gallagher E. J., LeRoith D. Minireview: IGF, Insulin, and Cancer. Endocrinology. 2011;152(7):2546-2551. https://doi.org/10.1210/en.2011-0231
5. Masternak M. M., Bartke A., Wang F., Spong A., Gesing A. [et al.]. Metabolic effects of intra-abdominal fat in GHRKO mice. Aging cell.2012;11(1):73-81. https://doi.org/10.1210/en.2011-0231
6. Ismail K., Nussbaum L., Sebastiani P., Andersen S., Perls T. [et al.]. Compression of morbidity is observed across cohorts with exceptional longevity. Journal of the American Geriatrics Society. 2016;64(8):1583-1591. https://doi.org/10.11/jgs.14222
7. Wolfson M., Budovsky A., Tacutu R., Fraifeld V. The signaling hubs at the crossroad of longevity and agerelated disease networks.The International Journal of Biochemistry & Cell Biology. 2009;41(3):516-520. https://doi.org/10.1016/j.biocel.2008.08.026
8. Yang J., Huang T., Song W. M., Petralia F., Mobbs C. V. [et al.]. Discover the network mechanisms underlying the connections between aging and age-related diseases. Scientific Reports. 2016;6:32566. https://doi.org/10.1038/srep32566
9. Kennedy B. K., Berger S. L., Brunet A., Campisi J., Cuervo A. M. [et al.]. Geroscience: linking aging to chronic disease. Cell. 2014;159(4):709-713. https://doi.org/10.1016/j.cell.2014.10.039
10. Kumar V., Abbas A. K., Aster J. C. Robbins & Cotran Pathologic Basis of Disease E-Book: Elsevier Health Sciences; 2014.
11. López-Otín C., Blasco M. A., Partridge L., Serrano M., Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-1217. https://doi.org/10.1016/j.cell.2013.05.039
12. Benayoun B. A., Pollina E. A., Brunet A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nature Reviews Molecular Cell Biology.2015;16(10):593-610. https://doi.org/10.1038/nrm4048
13. Warburg M., Møller H. U. Dystrophy: a revised definition. Journal of Medical Genetics.1989;26(12):769-771. https://doi.org/10.1136/jmg.26.12.769
14. de Magalhães J. P. The scientific quest for lasting youth: prospects for curing aging. Rejuvenation Research. 2014;17(5):458-467. https://doi.org/10.1089/rej.2014.1580
15. Campana L., Iredale J. P. Regression of Liver Fibrosis. Seminars in Liver Disease. 2017;37(1):1-10. https://doi.org/10.1055/s-0036-1597816
16. Kamble R. B., Babu S., Nagaraj D., Mudakavi S. J. Time bound regression of pituitary hyperplasia in primary pituitary hypothyroidism following treatment. West African Journal of Radiology. 2016;23(1):20. https://doi.org/10.4103/1115-3474.162145
17. Moskalev A. A., Proshkina E. N., Belyi A. A., Solovyev I. A. Genetics of aging and longevity. Russian Journal of Genetics: Applied Research. 2017;7(4):369-384. https://doi.org/10.1134/S2079059717040074
18. Ueha S., Shand F. H., Matsushima K. Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis. Frontiers in Immunology. 2012;10(3):71. https://doi.org/10.3389/fimmu.2012.00071
19. De Martinis M., Franceschi C., Monti D., Ginaldi L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Letters.2005;579(10):2035-2039.
https://doi.org/10.1016/j.febslet.2005.02.055
20. Bohomolets O. O. The prolongation of life.Translated by Karpovich PV MD, Bleeker S. New York: Essential Books, Duell, Sloan & Pearce; 1946.
21. Moskalev A., Shaposhnikov M., Solovev I. Studying the geroprotective effects of inhibitors suppressing agingassociated signaling cascades in model organisms. Medical news of North Caucasus. 2017;12(3):342-347. https://doi.org/10.14300/mnnc.2017.12090
22. Jellinger K. A., Attems J. Challenges of multimorbidity of the aging brain: a critical update. Journal Neural Transmitters (Vienna). 2015;122(4):505-521. https://doi.org/10.1007/s00702-014-1288-x
23. Satoh A., Imai S. I., Guarente L. The brain, sirtuins, and ageing. Nature reviews Neuroscience. 2017;18(6):362-374. https://doi.org/10.1038/nrn.2017.42
24. Schochet S. S. Neuropathology of aging. Neurologic Clinics. 1998;16(3):569-580. https://doi.org/10.1016/S0733-8619(05)70081-5
25. Kawakami R., Nakagami H., Noma T., Ohmori K., Kohno M. [et al.]. RANKL system in vascular and valve calcification with aging. Inflammation and Regeneration.2016;36(1):10. https://doi.org/10.1186/s41232-016-0016-3
26. Lin M., Lin S. L., Wang K. L., Kuo H. W., Tak T. Effect of aging on human circulatory system in normotensive healthy subjects. The International journal of angiology: official publication of the International College of Angiology, Inc. 2014;23(4):233-242. https://doi.org/10.1055/s-0034-1374735
27. Brack A. S., Conboy M. J., Roy S., Lee M., Kuo C. J. [et al.]. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science.2007;317(5839):807-810.https://doi.org/10.1126/science.1144090
28. Hulver M. W., Dohm G. L. The molecular mechanism linking muscle fat accumulation to insulin resistance. Proceedings of the Nutrition Society. 2004;63(2):375-380. https://doi.org/10.1079/PNS2004351
29. Siparsky P. N., Kirkendall D. T., Garrett W. E. Muscle changes in aging: understanding sarcopenia. Sports health. 2014;6(1):36-40. https://doi.org/10.1177/1941738113502296
30. Sousa-Victor P., Garcia-Prat L., Serrano A. L., Perdiguero E., Munoz-Canoves P. Muscle stem cell aging: regulation and rejuvenation. Trends in Endocrinology and Metabolism: TEM. 2015;26(6):287-296. https://doi.org/10.1016/j.tem.2015.03.006
31. Almeida M., O’Brien C. A. Basic biology of skeletal aging: role of stress response pathways. The Journals of Gerontology: Series A. 2013;68(10):1197-1208. https://doi.org/10.1093/gerona/glt079
32. Boskey A. L. Coleman R. Aging and bone. Journal of Dental Research. 2010;89(12):1333-1348. https://doi.org/10.1177/0022034510377791
33. McClung M., Baron R., Bouxsein M. An update on osteoporosis pathogenesis, diagnosis, and treatment. Bone. 2017;98:37. https://doi.org/10.1016/j.bone.2017.02.013
34. Khavkin J., Ellis D. A. Aging skin: histology, physiology, and pathology. Facial Plastic Surgery Clinics of North America. 2011;19(2):229-234. https://doi.org/10.1016/j.fsc.2011.04.003
35. Krutmann J., Bouloc A., Sore G., Bernard B. A., Passeron T. The skin aging exposome. Journal of Dermatological Science. 2017;85(3):152-161. https://doi.org/10.1016/j.jdermsci.2016.09.015
36. Montagna W., Carlisle K. Structural changes in aging human skin. The Journal of Investigative Dermatology.1979;73(1):47-53. https://doi.org/10.11/1523-1747.ep12532761
37. Brunt E. M., Janney C. G., Di Bisceglie A. M., Neuschwander-Tetri B. A., Bacon B. R. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. American Journal of Gastroeterology.1999;94(9):2467-2474. https://doi.org/10.11/j.1572-0241.1999.01377.x
38. D’Souza A. L. Ageing and the gut. Postgraduate Medical Journal. 2007;83(975):44-53. https://doi.org/10.1136/pgmj.2006.049361
39. Sheedfar F., Di Biase S., Koonen D., Vinciguerra M. Liver diseases and aging: friends or foes? Aging Cell.2013;12(6):950-954. https://doi.org/10.11/acel.12128.
40. Mora A. L., Rojas M., Pardo A., Selman M. Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease. Nature reviews Drug discovery. 2017;16(11):755-772. https://doi.org/10.1038/nrd.2017.170
41. Selman M., Pardo A. Revealing the pathogenic and agingrelated mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model. American journal of respiratory and critical care medicine. 2014;189(10):1161-1172. https://doi.org/10.1164/rccm.201312-2221PP
42. Arieti S. The pineal gland in old age. Journal of neuropathology and experimental neurology. 1954;13(3):482-491.
43. Sano T., Kovacs K. T., Scheithauer B. W., Young W. F. Aging and the human pituitary gland. Mayo Clinic proceedings. 1993;68(10):971-977. https://doi.org/10.1016/S0025-6196(12)62269-1
44. Jasim S., Gharib H. Thyroid and Aging. Endocrine Practice. 2017;24(4):369-374. https://doi.org/10.4158/EP171796.RA
45 Volkov V. P. Funkcionalnaya morfologiya parashchitovidnyh zhelyoz cheloveka v . Sovremennaya medicina: aktualnye voprosy. Modern medicine: current issues. 2014;32:6-16. (In Russ.).
46. Steinmann G. G. Changes in the Human Thymus During Aging. In: Müller-Hermelink H. K., ed. The Human Thymus: Histophysiology and Pathology. Berlin, Heidelberg: Springer Berlin Heidelberg; 1986.
47. Dobbie J. W. Adrenocortical nodular hyperplasia: the ageing adrenal. The Journal of Pathology. 1969;99(1):1-18. https://doi.org/10.1002/path.1710990102
48. Neville A. M., O’Hare M. J. Histopathology of the human adrenal cortex. Clinics in endocrinology and metabolism.1985;14(4):791-820. https://doi.org/10.1016/S0300-595X(85)80078-5
49. Proshchina A. E., Barabanov V. M., Krivova Y. S., Savelyev S. V. Structure and immunohystochemical changes of human pancreas in aging and diabetes mellitus. Morphological Newsletter. 2011;19(2):56-61.
50. Laszczyńska M., Brodowska A., Starczewski A., Masiuk M., Brodowski J. Human postmenopausal ovary – hormonally inactive fibrous connective tissue or more? Histology and histopathology. 2008;23(2):219-226. https://doi.org/10.14670/HH-23.219
51. Paniagua R., Martin A., Nistal M., Amat P. Testicular involution in elderly men: comparison of histologic quantitative studies with hormone patterns. Fertility and Sterility. 1987; 47(4): 671-679. https://doi.org/10.1016/S0015-0282(16)59120-1
52. Hommos M. S., Glassock R. J., Rule A. D. Structural and Functional Changes in Human Kidneys with Healthy Aging. Journal of the American Society of Nephrology.2017;28(10):2838-2844. https://doi.org/10.1681/ASN.2017040421
53. Zhou X. J., Rakheja D., Yu X., Saxena R., Vaziri N. D., Silva F. G. The aging kidney. Kidney International. 2008;74(6):710-720. https://doi.org/10.1038/ki.2008.319
54. Griebling T. L. Geriatricurology. NewYork: Springer; 2014.

Keywords: aging, alteration, typical pathological processes