logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Stud y of levels of neurotropic autoantibodies in patients with chronic low back pain

[Neurology]
Yury Simches; Sergei Karpov; Irina Vishlova; Vladimir Baturin;

The aim of the study was to comprehensively evaluate the change in the levels of autoantibodies to the S-100 protein in patients with acute and chronic pain in the lower back to determine the involvement of this protein in the pathological process within the systemic immune response to ongoing pain afferentation. High levels of antibodies to protein S-100 were revealed in pain syndrome, their dynamic evaluation was carried out, a possible pathogenetic role.

Download

References:
1. Poletayev A. B. Fiziologicheskaya immunologiya (estestvennye autoantitela i problemy nanomeditsiny). Moscow: «MIKLOSH»; 2010. (In Russ.).
2. Poletayev A. B. Antibodies to antigens of nervous tissue and pathology of the nervous system. Vestnik MEDSI. – Journal MEDSI. 2011;(13):14-21. (In Russ.).
3. Poletayev A. B., Morozov S. T., Kovalev I. E. Regulyatornaya metasistema. Immunoneyroendokrinnaya regulyatsiya gomeostaza. Moscow: «Meditsina»; 2002. (In Russ.).
4. Danilov A. B., Prishchepa A. V. Neuroimmunological mechanisms of headache development. Russky meditsinsky zhurnal. – Russian Medical Journal. 2015;29:7-8. (In Russ.).
5. Sepiashvili R. I. The immune system of the brain and cerebrospinal fluid. Allergologiya i immunologiya. – Allergology and Immunology. 2015;16(4):26- 38. (In Russ.).
6. Vyshlova I. A., Karpov S. M., Starodubtsev A. I. Neuroimmunological mechanisms of chronic pain syndrome. Nevrologiya, neyropsikhiatriya, psikhosomatika. – Neurology, neuropsychiatry, psychosomatics. 2016;8(2):113-116. (In Russ.). https://doi.org/10.14412/2074-2711-2016-2
7. Simkhes Yu. V., Karpov S. M., Baturin V. A., Vyshlova I. A. Role of proteins S100 in the pathogenesis of pain syndromes. Nevrologiya, neyropsikhiatriya, psikhosomatika. – Neurology, neuropsychiatry, psychosomatics. 2016;8(4):62-64. (In Russ.). https://doi.org/10.14412/2074-2711-2016-4-62-64
8. Heizmann C. W., Fritz G., Schäfer B. W. S100 proteins: structure, functions and pathology. Front Biosci. 2002;1(7):1356-1368.

Keywords: chronic back pain, neuroimmunology, protein S-100


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy