• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2018.13129

Dynamics of permanent cerebral hypoxia of rats depending on individual features of higher nervous activity and sex

Vladimir Chrishtop; Olga Pakhrova; Tatiana Rumyantseva;

The dynamics of lethality and neurological deficit in permanent cerebral hypoxia was analyzed in 197 rats divided on the basis of the level of stress resistance, development of cognitive functions and sex in subgroups using the «open field» test and the «Morris water labyrinth». The neurological deficit was assessed using the tests of McGraw and Garcia. It was found that high lethality in an acute period in rats is associated with a high initial level of development of cognitive functions and low stress tolerance. The neurological deficit was more pronounced in the subgroups of males and stress-nonresistant animals. In a subgroup of rats with a high level of cognitive abilities, significantly more pronounced neurologic disorders were detected only in the Garcia test on the first day of the experiment. In later periods, in animals with a high level of development of cognitive processes, a second peak of lethality was observed on the 8–28 days after the operation. Factors associated with a high level of neurological deficit on the 6th day of the experiment were: male sex and low stress resistance of animals.

Download

References:
1. Ivannikova N. O., Pertsov S. S., Krylin V. V. Features of the content of biogenic amines in the cerebral cortex during experimental intracerebral hemorrhage in rats with different behavioral activity. Byulleten’ ehksperimental’noj biologii i meditsiny. – Bulletin of Experimental Biology and Medicine. 2012;153(5):653-658. (In Russ.).
2. O’Mahony C. M., Clarke G., Gibney S., Dinan T. G., Cryan J. F. Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression. Pharmacol. Biochem. Behav. 2011;97(4):690-699.
3. Аlferova V. V., Uzbekov M. G., Misionzhnik E. Yu., Gekht А. B. The clinical significance of humoral compensatory reactions in the acute period of ischemic stroke. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. – Journal of Neurology and Psychiatry. S. S. Korsakov. 2011;(8):36-40. (In Russ.).
4. Koplik E. V. Method for determining the criterion for the resistance of rats to emotional stress. Vestnik novykh meditsinskikh tekhnologij. – Bulletin of new medical technologies. 2002;IX(1):16-18. (In Russ.).
5. Gafarova M. Eh., Naumova G. M., Gulyaev M. V., Koshelev V. B., Sokolova I. А., Domashenko M. А. Aggregation-disaggregation and deformability of erythrocytes in modeling ischemic stroke in rats. Regionarnoe krovoobrashhenie i mikrotsirkulyatsiy. – Regional blood circulation and microcirculation. 2015;14(2,54):63- 69. (In Russ.).
6. Dajneko А. S., Shmonin А. А., Shumeeva А. V., Kovalenko А. E., Mel’nikova E. V., Vlasova T. D. Methods for assessing neurological deficits in rats after a 30-minute focal cerebral ischemia in the early and late stages of the postischemic period. Regionarnoe krovoobrashhenie i mikrotsirkulyatsiy. – Regional blood circulation and microcirculation. 2014;13(1,49):68-78. (In Russ.).
7. Piradov M. А., Gulevskaya T. S., Ryabinkina Yu. V., Gnedovskaya E. V. Severe stroke and multiple organ failure syndrome. Zhurnal nevrologii im. B. M. Man’kovskogo. – Journal of Neurology of B. M. Mankovsky. 2013;(1):26-30. (In Russ.).
8. Lai T. W., Zhang S., Wang Y. T. Excitotoxicity and stroke: Identifying novel targets for neuroprotection. Progress in Neurobiology. 2014;(115):157-188. 9. Barber P. A. Magnetic Resonance Imaging of Ischemia Viability Thresholds and the Neurovascular Unit. Sensors. 2013;(13):6981-7003. https://doi.org/10.3390/s130606981
10. Kaur H., Prakash A., Medhi B. Drug therapy in stroke: from preclinical to clinical studies. Pharmacology. 2013;92(5- 6):324-334.
11. Red’kina А. V. Role of GABA- and NMDA-peptepropev in rat brain in modulation of latent inhibition: the importance of emotional and genetic factors. Tomsk, 2014. (In Russ.).
12. Lyon L., Burnet P. W., Kew J. N., Corti C., Rawlins J. N. [et al.]. Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition. Neuropsychopharmacology. 2011;36(13):2616-2628. https://doi.org/10.1038/npp.2011.145
13. Huang M., Panos J. J., Kwon S., Oyamada Y., Rajagopal L., Meltzer H. Y. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. J. Neurochem. 2014;128(6):938-949. https://doi.org/10.1111/jnc.12512
14. Aharoni E., Vincent G. M., Harenski C. L., Calhoun V. D., Sinnott-Armstrong W., Gazzaniga M. S., Kiehl K. A. Neuroprediction of future rearrest. Proceedings of the National Academy of Sciences. 2013;110(15):6223-6228. https://doi.org/10.1073/pnas.1219302110
15. Okruszek Ł., Dolan K., Lawrence M., Cella M. The beat of social cognition: Exploring the role of heart rate variability as marker of mentalizing abilities. Soc. Neurosci. 2017;12(5):489-493. https://doi.org/10.1080/17470919.2016.1244113
16. Williams D. P., Thayer J. F., Koenig J. Resting cardiac vagal tone predicts intraindividual reaction time variability during an attention task in a sample of young and healthy adults. Psychophysiology. 2016;53(12):1843-1851. https://doi.org/10.1111/psyp.1273
17. Spasov A. A., Fedorchuk V. Yu., Gurova N. A., Cheplyaeva N. I., Reznikov E. V. Methodological approach for the study of neuroprotective activity in the experiment. Vedomosti Nauchnogo tsentra ėkspertizy sredstv meditsinskogo primeneniia. – Statements of the scientific center for the examination of medical devices. 2014;(4):39-45. (In Russ.).
18. Bogolepova I. N., Medvedeva L. I., Agapov P. A. Gender peculiarities of the structure of the prefrontal cortex of the brain of men and women. Morfologicheskie vedomosti. – Morphological sheets. 2016;(1):9-15. (In Russ.).
19. Ishihara Y., Fujitani N., Sakurai H., Takemoto T., Ikeda-Ishihara N. [et al.]. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures. Steroids. 2016;(113):71-77. https://doi.org/10.1016/j.steroids.2016.06.004
20. Kareva E. N., Olejnikova O. M., Panov V. O., Shimanovskij N. L., Skvortsova V. I. Estrogens and the brain. Vestnik RАMN, Аktual’nye voprosy ehndokrinologii. – Herald of the Russian Academy of Medical Sciences, Actual questions of endocrinology. 2012;(2):48-59. (In Russ.).

Keywords: lethality, neurological deficit, sex, stress resistance, cognitive functions, hypoxia