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Dynamics of permanent cerebral hypoxia of rats depending on individual features of higher nervous activity and sex


Vladimir Chrishtop; Olga Pakhrova; Tatiana Rumyantseva;

The dynamics of lethality and neurological deficit in permanent cerebral hypoxia was analyzed in 197 rats divided on the basis of the level of stress resistance, development of cognitive functions and sex in subgroups using the «open field» test and the «Morris water labyrinth». The neurological deficit was assessed using the tests of McGraw and Garcia. It was found that high lethality in an acute period in rats is associated with a high initial level of development of cognitive functions and low stress tolerance. The neurological deficit was more pronounced in the subgroups of males and stress-nonresistant animals. In a subgroup of rats with a high level of cognitive abilities, significantly more pronounced neurologic disorders were detected only in the Garcia test on the first day of the experiment. In later periods, in animals with a high level of development of cognitive processes, a second peak of lethality was observed on the 8–28 days after the operation. Factors associated with a high level of neurological deficit on the 6th day of the experiment were: male sex and low stress resistance of animals.

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Keywords: lethality, neurological deficit, sex, stress resistance, cognitive functions, hypoxia


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