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The effect of therapy with bisphosphоnates on the parameters of central pressure and arterial stiffness during daily monitoring in women with postmenopauzal osteoporosis and coronary heart disease

[Internal diseases]
Svetlana Tsarenok; Vladimir Gorbunov; Tatiana Aksenova;

The effect of therapy with bisphosphonates on the parameters of central pressure and arterial stiffness during ambulatory blood pressure monitoring (ABPM) was evaluated. The open, prospective comparative study included 64 women aged 56 to 78 years with a verified diagnosis of coronary heart desease (CHD) and postmenopausal osteoporosis. Patients were prescribed Alendronate 70 mg per week. The follow-up was 12 months. Daily monitoring of central blood pressure and parameters of arterial stiffness was performed on the apparatus BPLabv. 3.2 prior to the initiation of antiresorptive therapy against baseline CHD therapy. Dynamically ABPM was performed 6 and 12 months after the beginning of treatment. In 6 months a significant decrease in the maximum daily pulse wave velocity (PWV) was detected: the maximum per day at 0.8 mm (p=0.04), mean Alx HR. After 12 months of treatment with bisphosphonates (BP), there was a decrease in the level of SBPao, mean BPao and pulse aortic pressure. The PWV max decreased by 1.3 m/s from the baseline, decrease of ASI, AASI, Alx, mean Alx HR was registered.
BP therapy in women with postmenopausal osteoporosis and with CHD is accompanied by a decrease in central pressure after 12 months treatment and a decrease in PWV max after 6 and 12 months treatment.

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Keywords: osteoporosis, CHD, arterial stiffness, central pressure, bisphosphonates


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