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Matrix metalloproteinases: role in cardiac remodeling in patients with connective tissue dysplasia

[Internal diseases]
Madina Djazaeva; Natalia Gladkikh; Vladimir Reshetnikov; Alexandr Yagoda;

57 men and 43 women, aged 22.0±4.2 years were examined to determine the clinical and prognostic value of matrix metalloproteinases in heart remodeling in CTD. Serum concentrations of MMP-1, MMP-9, TIMP-1 were determined by ELISA («Cloud-Clone Corp.», China). Imbalance of MMP-1, MMP-9 and their inhibitor – TIMP-1 was revealed in patients with CTD. Significant increase in MMP-1 level was registered in cases of MVP with myxomatous degeneration and mitral regurgitation of II degree. Risk of cardiac remodeling progression at three-year follow-up increases in cases of elevated of MMP-1/ TIMP-1 coefficient. Identified changes in the MMPs system in patients with CTD may be used as additional criteria of severity and determination of probability of progression of heart connective tissue structures remodeling.

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Keywords: matrix metalloproteinases, connective tissue dysplasia, cardiac remodeling


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