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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Bone marrow aplasia in a patient treated with Cefotaxime

[Notes from practice]
Leonid Dvoretsky; Viktor Yakovlev; Margarita Suvorova; Elena Sergeeva; Georgii Zayratyants;

Description of the first case of aplastic anemia caused by сefotaxime, a third-generation сephalosporin, with lethal outcome is presented. Clinical record of a patient and post-mortem examination results are given. Possible mechanisms of cytopenias induced by сephalosporin antibiotics are discussed.

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References:
1. Mariotti G., Caberlon S., Bertinato E., Podda G., Pugliano M. T. [et al.] Primary autoimmune neutropenia in adults: case report and review of the literature. Transfusion. 2014;54:2906-2910. https://doi.org/10.1111/trf.12711
2. Uy N., Thiagarajan P., Musher D. M. Cephalosporin side chain idiosyncrasies: a case report of ceftriaxoneinduced agranulocytosis and review of literature. Open Forum Infect. Dis. 2015;2(1):1-4. https://doi.org/10.1093/ofid/ofv007
3. Marie J. P. Antibiotics and hematopoiesis: toxicity of betalactam on in vitro granulopoiesis. Pathol. Biol. (Paris). 1987;35(10Pt2):1408-1411. 4. Phull P., Lerner A. Agranulocytosis Secondary to Ceftaroline Use: A Case Report and Review of the Literature. Journal of Hematology. 2016;5(3):103-105. https://doi.org/10.14740/jh281w
5. Al Qahtani S. A. Drug-induced megaloblastic, aplastic, and hemolytic anemias: current concepts of pathophysiology and treatment. Int. J. Clin. Exp. Med. 2018;11(6):5501- 5512.
6. Han J., Lee H., Hyojeong H., Lee Y. S., Yun-Jeong B. [et al.] Cephalosporin-induced recurrent aplastic anemia. Eur. J. Clin. Pharmacol. 2011;67:317-318. https://doi.org/10.1007/s00228-010-0913-3

Keywords: cephalosporin antibiotics, aplastic anemia, agranulocytosis


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Pyatigorsk State Research Institute of Balneotherapeutics
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