Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 865 2352511, +7 865 2353229.


Polymorphic variants of the TLR6 gene in adult patients with bronchial asthma

Lyudmila Barycheva; Liliya Shushanova; Alexandr Yagoda; Marina Golubeva; Milana Minasyan;

Immunogenetic studies were performed in 65 people with allergic bronchial asthma (BA) and 35 with non-allergic BA. This study established that the molecular genetic markers for an increased risk of allergic BA are allele TLR6 745C and TLR6 C745T. This association of polymorphic markers of the TLR6 gene is confirmed only for allergic BA. An increased
risk of allergic asthma was found in carriers of the common allele TLR6 745C and those with the heterozygous genotype C745T.


1. Alexis N. E. Biomarker sampling of the airways in asthma. Curr. Opin. Pulm. Med. 2014;20(1):46-52. https://doi.org/10.1097/MCP.0000000000000010
2. Maisonneuve C., Bertholet S., Philpott D. J., De Gregorio E. Unleashing the potential of NOD- and Tolllike agonists as vaccine adjuvants. Proc. Sci. 2014;111(34):12294-12299. https://doi.org/10.1073/pnas.1400478111
3. Sathish V., Thompson M. A., Sinha S., Sieck G. C. Prakash Y. S. [et al.] Inflammation, caveolae and CD38- mediated calcium regulation in human airway smooth muscle. Biochim. Biophys. Acta. 2014;1843(2):346- 351. https://doi.org/10.1016/j.bbamcr.2013.11.011
4. Koponen P., Vuononvirta J., Nuolivirta K., Helminen M., He Q. [et al.] The association of genetic variants in tolllike receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy. Pediatric Infect. Dis. J. 2014;33(5):463-466. https://doi.org/10.1097/INF.0000000000000253
5. Kormann M. S., Depner M., Hartl D., Klopp N., Illig T. [et al.] Toll-like receptor heterodimer variants protect from childhood asthma. J. Allergy Clin. Immunol. 2008;122:86- 92. https://doi.org/10.1016/j.jaci.2008.04.039

Keywords: bronchial asthma, Toll-like receptors, gene polymorphism

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy