310 Mira Street, Stavropol, Russia, 355017
+7 8652 352524; +7 8652 353229.
+7 8652 352524.
The journal is included into The list of leading scientific periodicals.
Among 344 myasthenia patients living in the Krasnodar Territory were examined. Of these, 246 were women (71.5 %) and 98 men (28.5 %), the ratio of men to women was 1:2.5. The average age of patients with myasthenia gravis at the onset of disease was 46.2±0.97. In the majority of cases, the generalized form of the disease prevailed (82.8 %). The eye shape was revealed in 16.3 % of cases, craniopharyngeal in 0.9 % of cases, respectively. The pathology of the thymus gland was revealed in 36 patients. Early onset (up to 40 years) of myasthenia gravis was observed in 142 patients, 114 debut women and 28 men respectively. The ratio of men to women was 1: 4. Oculomotor disorders in the form of asymmetric ptosis and diplopia (weakness in extraocular muscles) with minimal lesion in the bulbar group of muscles and skeletal muscles prevailed in the clinical picture of the disease debut in these patients. 93 patients were diagnosed late onset (after 60 years) of myasthenia gravis, including 60 women and 33 men. The ratio was 1: 1.8. At the onset of the disease, weakness and pathological fatigue in the masticatory muscles, the muscles of the extensor muscles of the neck, and in the deltoid muscle, with minimal damage to the triceps brachii muscle and extraocular muscles prevailed in this group of patients.
1. Agafonov B. V., Kotov S. V., Sidorova O. P. Myasthenia and congenital myasthenic syndromes. Moscow, 2013.
2. Phillips L. H. The epidemiology of myasthenia gravis. Semin. Neurol. 2004;24 (1):17-20. https://doi.org/10.1055/s-2004-829593
3. Carr A. S., Cardwell C. R., McCarron P. O. [et al.] A systematic reviiew of population based epidemiological studies in Мyasthenia Gravis. ВМС neurology. 2010;10:46. https://doi.org/10.1186/1471-2377-10-46
4. Chien-Hsu L., Hung-Fu T. Nationwide Population-Based Epidemiological Study of Myasthenia Gravis in Taiwan. Neuroepidemiology. 2010;35:66–71. https://doi.org/10.1159/000311012
5. Romanova T. V. Samara epidemiological research of myasthenia gravis. Saratov Journal of Medical Scientific Research. 2012;8(1):91-95.
6. Khatkhe Y. A., Zabolotskikh N. V., Terpelets S. A. Epidemiologic and populational aspects of myasthenia gravis in the Krasnodar Region. Neuromuscular Diseases. 2018;8(1):28-33. https://doi.org/10.17650/2222-8721-2018-8-1-28-33
7. Sanadze A. G. Myasthenia and myasthenic syndromes. 2nd ed. Moscow: GEOTAR – Media, 2017.
8. Bondarenko L. A., Penina G. O. Epidemiology and clinicofunctional characteristics and quality of life of myasthenia gravis patients in the inhabitants of the European Noth. International neurological journal. 2009;1:71-75.
9. Cousin M. I., Hecht B. M. Myasthenia. M.: Medicine, 1996. 10. Alekseeva T. M., Kosachev V. D., Khalmurzina A. N. Clinical and immunological features and treatment of myasthenia gravis in the elderly (review). Neuromuscular Diseases. 2016;6(3):10-16. https://doi.org/10.17650/2222-8721-2016-6-3-10-16
11. Gasymly E. D., Isaeva N. V., Prokopenko S. V., Andon Y. N. Epidemiological and clinical characteristics of myasthenia in the Krasnoyarsk region. Neuromuscular Diseases. 2017;7(4):33-38. https://doi.org/10.17650/2222-8721-2017-7-4-33-38
Keywords: myasthenia gravis, diagnosis, clinical picture, thymus gland