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Evaluating the pain response in children is difficult. Nevertheless, the search for methods with which to assess pain objectively in newborns with surgical pathology of the digestive tract remains urgent. Therefore, we conducted a study of the serum concentrations of pain markers (substance P and neurokinin A) in infants to determine the relation of each of these indicators to pain-intensity scales (COMFORT, VAS). This objective evaluation of pain in newborns allowed the provision of individualized care to these and other infants with necrotizing enterocolitis at various stages of the disease.
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Keywords: pain, substance P, neurokinin A, COMFORT, VAS, NEC, newborns