logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Polymorphism G-105A SEPS1 gene and mens’ infertility

[Urology]
Galina Myandina; Nina Kulchenko; Hasan Alhejoj;

Reproductive disorders in men are the cause of infertility of 30–40 % of infertile couples. The genetic factors play a great role in male infertility as they are detected in 15–30 % of men. The distributions of polymorphic variants of candidate genes relevant to male fertility in different populations are of great interest to explain the male idiopathic infertility. The aim of this study was to explore the association of the SEPS1 gene polymorphism G-105A (rs28665122) with pathospermia in infertile men in Moscow region. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect SEPS1 G-105A polymorphism in 26 cases and 24 controls. The results showed that the frequency of the minor allele A of geneSEPS1 is higher in men with pathospermia than in the control group of fertile men. Conclusion: The SEPS1 gene polymorphismG-105A is associated with idiopathic infertility in men with pathospermia and can be used to screen idiopathic infertility in men.

Download

References:
1. Iskhakova G. M., Izmajlova S. M., Izmajlov A. A. Genetic aspects of male infertility. Modern problems of science and education. 2015;3:85-87.
2. Kulchenko N. G. Oxidative stress in the development of non-obstructive azoospermia. Difficult patient. 2017;4- 5(15):44-46.
3. Tavokina L. V. Male infertility. Genetic aspect. Pochki. 2014;2(8):9-13.
4. Du X. A., Wang H. M., Dai X. X., Kou Y., Wu R. P. [et al.] Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pathway in Kashin-Beck disease. Osteoarthritis Cartilage.2015;23(2):210-216.
5. Kelly E., Greene C. M., Carolli T. P., McElvanney N. G., O’Neill S. J. Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency. J. Biol. Chem. 2009;284(25):16891-16897.
6. Martinez A., Santiago J. L., Varade J., Lamas J. R. Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases. BMC Genomics. 2008;9:329-331.
7. Santos L. R., Duraes C., Mendes A., Prazeres H., Alvelos M. I. [et al.] A polymorphism in the promoter region of the selenoprotein S gene (SEPS1) cjntributes to Hashimoto’s thyroiditis susceptibility. J. Clin. Endocrinol. Metab. 2014;99(4):19-23.
8. Sun H. Y., Liu T. B., Wang Q. C., Wu W. Q., He Y. J. Single nucleotide polymorphism in the SEPS1 gene may contribute to the risk of various human diseases: a metaanalysis. Ann. Hum. Biol. 2016;43(5):469-479.
9. Wang Y., Yang X., Zheng Y., Wu Z. H., Zhang X. A. [et al.] The SEPS1G-105A Polymorphism Is Associated with Risk of Spontaneous Preterm Birth in a Chinese Population. PLOS One. 2013;8(6):11-14.
10. Zhylkova I., Feskov A., Fedota A. FSHR gene polymorphisms causes male infertility. Open Journal of Genetics. 2016;6:1-8.

Keywords: idiopathic male infertility, genetic factor, gene SEPS1, G-105A polymorphism


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy