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Reproductive disorders in men are the cause of infertility of 30–40 % of infertile couples. The genetic factors play a great role in male infertility as they are detected in 15–30 % of men. The distributions of polymorphic variants of candidate genes relevant to male fertility in different populations are of great interest to explain the male idiopathic infertility. The aim of this study was to explore the association of the SEPS1 gene polymorphism G-105A (rs28665122) with pathospermia in infertile men in Moscow region. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect SEPS1 G-105A polymorphism in 26 cases and 24 controls. The results showed that the frequency of the minor allele A of geneSEPS1 is higher in men with pathospermia than in the control group of fertile men. Conclusion: The SEPS1 gene polymorphismG-105A is associated with idiopathic infertility in men with pathospermia and can be used to screen idiopathic infertility in men.
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Keywords: idiopathic male infertility, genetic factor, gene SEPS1, G-105A polymorphism