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ISSN 2073-8137

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Comparative characteristics of tissue expression of matrix metalloproteinases of benign and malignant melanocytic neoplasms of the skin

Inna Novikova; Ekaterina Komarova; Victoria Pozdniyakova; Maria Maksimova; Elena Ulyanova; Anastasia Grankina; Irina Dashkova; Larisa Vashchenko;

Expression of matrix metalloproteinases (MMP-2 and MMP-9) in tissues of benign (nevi, dysplastic nevus) and malignant skin pigmentation neoplasms in 60 patients by immunohistochemical method was studied.
MMP-9 expression in melanoma cells was 6 and 2.9 times higher than in nevi and dysplastic nevi. MMP-2 expression was maximal in dysplastic nevi and exceeded expression values in nevi by 1.4 times (p<0.05); there was no significant difference in the expression of MMP-2 between dysplastic nevi and melanoma. Thus, significant differences in the expression level of MMP-9 with the dynamics of the index increase in the «nevus – dysplastic nevus – melanoma» series are shown. A more pronounced intensity of staining of both MMPs (with a predominance of strongly and moderately positive reactions) was characteristic of tissues of the malignant neoplasms of the skin.


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Keywords: nevus, dysplastic nevus, melanoma, matrix metalloproteinases-2 and 9

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy