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ISSN 2073-8137

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The effect of resistin on the effectiveness of therapy of chronic glomerulonephritis

[Internal diseases]
Mikhail Batiushin; Aleksandra Razina; Aleksandr Kastanayan; Boris Vorob’ev;

The effect of the resistin level on the efficacy of pathogenetic therapy of patients with chronic glomerulonephritis was assessed. We examined 80 patients with CGN, of which 30 had nephrotic, 50 – nephritic variant. All patients were included during the exacerbation of glomerulonephritis and received pathogenetic therapy according to clinical protocols. The period of prospective follow-up was 12 months. In addition to clinical eamination and nephrobiopsy, all patients were tested for serum resistance in the serum by an enzyme immunoassay. Hyperresistinemia was associated with a more severe course of glomerulonephritis, mainly with nephrotic syndrome and a greater need for glucocorticoids and diuretics. The level of resistinemia had no independent effect on the probability of remission, but in combination with a high degree of hypertension, signs of renal dysfunction, tubulointerstitial lesions, hyperresistinemia reduced the possibility of complete remission in chronic glomerulonephritis.


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Keywords: resistin, chronic glomerulonephritis, nephrotic syndrome, nephritic syndrome

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy