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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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Clinical -neuromymonnological correlations in chronic brain ischemia

[Abstracts]
Mariya Baturina; Irina Dolgova; Marina Hibirtova; Farida Shamasurova;

Chronic brain ischemia is one of the common diseases in neurological practice, cognitive impairment is the core of its clinical picture. Clinico-neuroimmunological study of patients with different severity of CI was performed. The concentration of autoantibodies (AAB) to NMDA-receptors, to dopamine D2-receptors, to dopamine, to the S100 protein in the blood plasma was determined. It was revealed that the decrease in cognitive functions in patients with chronic brain ischemia of the 2nd stage is accompanied by an increase in the concentration of AAB to the S100 protein, to dopamine D2 receptors and to dopamine in the blood plasma. Neuroimmunological indices in patients with moderate CI are higher than in patients with mild CI.

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References:
1. Damulin I. V. Zhurn. Nevrologii i psihiatrii. – Journal of Neurology and Psychiatry. 2009;1:70-75.
2. Dolgova I. N., Starodubtsev A. I. Zhurn. Nevrologii i psihiatrii. – Journal of Neurology and Psychiatry. 2010;10:14-16.
3. Dolgova I. N., Starodubtsev A. I. Kubanskij nauchnyj medicinski jvestnik. – Kuban scientific medical bulletin. 2011;4:63-65.
4. McBain C. J., Mayer M. L. Physiol. Rev. 1994;74(3):723- 760.

Keywords: chronic brain ischemia, cognitive impairment, autoantibodies, NMDA-receptors, dopamine receptors, dopamine


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
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