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Chronic brain ischemia is one of the common diseases in neurological practice, cognitive impairment is the core of its clinical picture. Clinico-neuroimmunological study of patients with different severity of CI was performed. The concentration of autoantibodies (AAB) to NMDA-receptors, to dopamine D2-receptors, to dopamine, to the S100 protein in the blood plasma was determined. It was revealed that the decrease in cognitive functions in patients with chronic brain ischemia of the 2nd stage is accompanied by an increase in the concentration of AAB to the S100 protein, to dopamine D2 receptors and to dopamine in the blood plasma. Neuroimmunological indices in patients with moderate CI are higher than in patients with mild CI.
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Keywords: chronic brain ischemia, cognitive impairment, autoantibodies, NMDA-receptors, dopamine receptors, dopamine