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Nitrous oxide. Should it still be used in pediatric medicine ? (Part 1)

[Review]
Leo Booij;

Nitrous oxide (N2O) has been used in medicine for more than 165 years. By incidence was the analgesic effect recognized by Howard Wells. Originally was it thought to be a clean and anesthetic not causing a single adverse effect, and therefore was it considered the safest anesthetic. However, around 1956 was it recognized that some patients, after prolonged exposure developed, mostly transient, megaloblastic anemia and neurological disorders. Gradually became adverse effects more known. This resulted in discussions in the literature on the safety of N2O. Since the 1990’s are there indications that N2O administration in children during the period of brain development and in elderly persons has neurotoxic effects. This lead to the conclusion of many that N2O should no longer be used in medicine. However, other physicians have the opinion that there is no reason to stop the use of N2O.

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References:
1. Rymer, Samuel Lee. Remarks upon the Use of Nitrous Oxide in Dental Operations. Dental Review: A Quarterly Journal of Dental Science 1864 Jan., 1864.
2. Hilllischer Th. Ueber die allgemeine Verwendbarkeit der Lustgas-Sauerstoffnarkose in der Chirurgie. Wien, Frick, 1886.
3. Klikovich S. Nitrous oxide and experiences with its therapeutic administration. A. M. Kotomin, St Petersburg, 1881.
4. Klikowitscsh S. Ueber das Stickostoffoxydul als Anaestheticum bei Geburten. Archiv Fr Ginaekologie. 1881;18:81-108.
5. Dudley Wilmot Buxton. On the physiological action of nitrous oxide. London, Harrison & Sons. 1886.
6. Mennerick S., Jevtovic-Todorovic V., Todorovic S. M. [et al.] Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J. Neurosci. 1998;18:9716-9726.
7. Quock R. M., Best J. A., Chen D. C. [et al.] Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors. Eur. J. Pharmacol. 1990;175:97-100.
8. Chen D. C., Quock RM. A study of central opioid reception involvement in nitrous oxide analgesia in mice. Anaesth. Prog. 1990;37:181-185.
9. Branda E. M., Ramza J. T., Cahill F. J. [et al.] Role of brain dynorphin in nitrous oxide antinociception in mice. Pharmacol. Biochem. Behav. 2000;65:217-221.
10. Berkowitz B. A., Finck A. D., Ngai S. H. Nitrous oxide analgesia: Reversal by naloxone and development of tolerance. J. Pharmacol. Exp. Ther. 1977;203:539-547.
11. Hodges B. L., Gagnon M. J., Gillespie T. R. [et al.] Antagonism of nitrous oxide antinociception in the rat hot plate test by site-specific mu and epsilon opioid receptor blockade. J. Pharmacol. Exp. Ther. 1994;269:596-600.
12. Branda E. M., Ramza J. T., Cahill F. J. [et al.] Role of brain dynorphin in nitrous oxide antinociception in mice. Pharmacol. Biochem. Behav. 2000;65:217-221.
13. Ori C., Fordrice F., London E. D. Effects of nitrous-oxide and halothane on mu-opioid and kappa-opioid receptors in guinea-pig brain. Anesthesiology. 1989;70:541-544.
14. Singh R. H., Thaxton L., Carr S. [et al.] A randomized controlled trial of nitrous oxide for intrauterine device insertion in nulliparous women. Int. J. Gynaecol. Obstet. 2016; 135:145-148.
15. Zhang C., Davies M. F., Guo T. Z., Maze M. The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord. Anesthesiology. 1999;91:1401-1407.
16. Jevtovic-Todorovic V., Todorovic S. M., Mennerick S. [et al.] Nitrous oxide (laughing gas) is an NMDA antagonists, neuroprotectant and neurotoxin. Nature Medicine. 1998; 4:460-463.
17. Emmanouil D. E., Quock R. M. Advances in understanding the actions of nitrous oxide. Anesth. Prog. 2007;54:9-18.
18. Lassen H. C., Henriksen E., Neukirch F., Kristensen H. S. Treatment of tetanus; severe bone-marrow depression after prolonged nitrous-oxide anaesthesia. Lancet. 1956; 270:527–530.
19. Amess J. A., Burman J. F., Rees G. M. [et al.] Megaloblastic haemopoiesis in patients receiving nitrous oxide. Lancet. 1978;2:339–342.
20. Sahenk Z., Mendell J. R., Couri D., Nachtman J. Polyneuropathy from inhalation of N2O cartridges through a whipped-cream dispenser. Neurology. 1978; 28:485-487.
21. Layzer R. B. Myeloneuropathy after prolonged exposure to nitrous oxide. Lancet. 1978;2:1227-1230.
22. Layzer R. B., Fishman R. A., Schafer J. A. Neuropathy following abuse of nitrous oxide. Neurology. 1978;28:504-506.
23. Linde H. W., Bruce D. L. Occupational exposure of anesthetists to halothane, nitrous oxide and radiation. Anesthesiology. 1969;30:363-368.
24. Kugel G., Norris L. H., Zive M. A. Nitrous oxide and occupational exposure: it’s time to stop laughing. Anesth. Prog. 1989;36:252-257.
25. Brodsky J. B., Cohen E. N., Brown B. W. Jr. [et al.] Exposure to nitrous oxide and neurologic disease among dental professionals. Anesth. Analg. 1981;60:297-301.
26. Brodsky J. B., Cohen E. N. Adverse effects of nitrous oxide. Med. Toxicol. 1986;1:362-374.
27. Donaldson D., Meechan J. G: The hazards of chronic exposure to nitrous oxide: an update. Br. Dent. J. 1995; 178:95-100.
28. Rowland A. J., Baird D. D., Shore D. L. [et al.] Nitrous oxide and spontaneous abortion in female assistants. Am. J. Epidemiol. 1995;141:531-538.
29. Myles P. S., Leslie K., Silbert B. [et al.] A review of the risks and benefits of nitrous oxide in current anaesthetic practice. Anaesth. Intensive Care. 2004;32:165-172.
30. Vishnubhakat S. M., Beresford H. R. Reversible myeloneuropathy of nitrous oxide abuse: serial electrophysiological studies. Muscle Nerve. 1991;14:22–26.
31. Flippo T. S., Holder W. D. Jr. Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. Arch. Surg. 1993;128:1391-1395.
32. Moudgil G. C., Pandya A. R., Ludlow D. J. Influence of anaesthesia and surgery on neutrophil chemotaxis. Can. Anaesth. Soc. J. 1981;28:232-238.
33. Nunn J. F., O’Morain C. Nitrous oxide decreases motility of human neutrophils in vitro. Anesthesiology. 1982;56:45-48.
34. Leslie K., Myles P. S., Chan M. T. [et al.] Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial. Anesth. Analg. 2011;112:387-393.
35. Myles P. S., Leslie K., Chan M. T. [et al.] ENIGMA Trial Group. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology. 2007;107:221-231.
36. Myles P. S., Chan M. T., Kaye D. M. [et al.] Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function. Anesthesiology. 2008;109:657-663.
37. Hornbein T. F., Eger E. I. 2nd, Winter PM. [et al.]The minimum alveolar concentration of nitrous oxide in man. Anesth. Analg. 1982;61:553-556.
38. Andrews E. The oxygen mixture, a new-anaesthetic combination. Chicago Med. Exam. 1868;9:656-661.
39. Eger E. I. II, Saidman L. J. Hazards of nitrous oxide anesthesia in bowel obstruction and pneumothorax. Anesthesiology. 1965;26:61-66.
40. Wolf G. L., Capuano C., Hartung J. Effect of nitrous oxide on gas bubble volume in the anterior chamber. Arch. Ophthalmol. 1985;103:418-419.
41. Nakao K., Komasawa N., Fujiwara S. [et al.][Difference in nitrous oxide-mediated increases in intracuff pressure between two tracheal tubes in a simulated pediatric lung model]. Masui. 2014;63:578-581.
42. van Zundert T., Brimacombe J.Comparison of cuff-pressure changes in silicone and PVC laryngeal masks during nitrous oxide anaesthesia in spontaneously breathing children. Anaesthesiol. Intensive Ther. 2012;44:63-70.
43. Miyashiro R. M., Yamamoto L. G.: Endotracheal tube and laryngeal mask airway cuff pressures can exceed critical values during ascent to higher altitude. Pediatr. Emerg. Care. 2011;27:367-370.
44. Atalay C., Aykan Ş., Can A. [et al.] Tracheal Rupture due to Diffusion of Nitrous Oxide to Cuff of High-Volume, Low-Pressure Intubation Tube. Eurasian J. Med. 2009;41:136-139.
45. Zhang J., Zhao Z., Chen Y., Zhang X. New insights into the mechanism of injury to the recurrent laryngeal nerve associated with the laryngeal mask airway. Med. Sci. Monit. 2010;16:HY7-9.
46. Goldmann K., Dieterich J., Roessler M. Laryngopharyngeal mucosal injury after prolonged use of the ProSeal LMA in a porcine model: a pilot study. Can. J. Anaesth. 2007;54:822-828.
47. Maino P., Dullenkopf A., Bernet V., Weiss M. Nitrous oxide diffusion into the cuffs of disposable laryngeal mask airways. Anaesthesia. 2005;60:278-282.
48. Schloss B., Rice J., Tobias J. D.The laryngeal mask in infants and children: what is the cuff pressure? Int. J. Pediatr. Otorhinolaryngol. 2012;76:284-286.
49. Sharma B., Gupta R., Sehgal R. [et al.] ProSeal™ laryngeal mask airway cuff pressure changes with and without use of nitrous oxide during laparoscopic surgery. J. Anaesthesiol. Clin. Pharmacol. 2013;29:47-51.
50. Lockwood A. J., Yang Y. F. Nitrous oxide inhalation anaesthesia in the presence of intraocular gas can cause irreversible blindness. Br. Dent. J. 2008; 204:247-248.
51. Lee E. J. Use of nitrous oxide causing severe visual loss 37 days after retinal surgery. Br. J. Anaesth. 2004;93:464-466.
52. Aström S., Kjellgren D., Mönestam E. [et al.] Nitrous oxide anesthesia and intravitreal gas tamponade. Acta. Anaesthesiol. Scand. 2003;47:361-362.
53. Silvanus M. T., Moldzio P., Bornfeld N. [et al.] Visual loss following intraocular gas injection. Dtsch. Arztebl. Int. 2008;105:108-112.
54. Kodjikian L., Fleury J., Garweg J. [et al.] Blindness after nitrous oxide anesthesia and internal gas tamponade. J. Fr. Ophtalmol. 2003;26:967-971.
55. Tanchyk A., Tanchyk A. The absolute contraindication for using nitrous oxide with intraocular gases and other dental considerations associated with vitreoretinal surgery. Gen. Dent. 2013;61(6):e6-7.
56. Munson E. S., Merrick H. C. Effect of nitrous oxide on venous air embolism. Anesthesiology. 1966;27:783-787.
57. Diemunsch P. A., Noll E., Pottecher J. [et al.] Impact of nitrous oxide on the haemodynamic consequences of venous carbon dioxide embolism: An experimental study. Eur. J. Anaesthesiol. 2016;33:356-360.
58. Akca O., Lenhardt R., Fleischmann E. [et al.] Nitrous oxide increases the incidence of bowel distension in patients undergoing elective colon resection. Acta Anaesthesiol. Scand. 2004;48:894-898.
59. Salanitre E., Rackow H. N2O volumes absorbed and excreted during N2O anesthesia in children. Anesth. Analg. 1976;55:95-99.
60. Taheri S., Eger E. I. II. A demonstration of the concentration and second gas effects in humans anesthetized with nitrous oxide and desflurane. Anesth. Analg. 1999;89:774-780.
61. Banks R. G. S., Henderson R. J., Pratt J. M. Reactions of gases in solution. Part III: some reactions of nitrous oxide with transition-metal complexes. J. Chem. Soc. 1968;3:2886-2889.
62. Banks R. G. S., Henderson R. J., Pratt J. M. Reactions of gases in solution. Part III: Some reactions of nitrous oxide with transition metal complexes. Chemical Communications. 1967;8:387-388.
63. Deacon R., Lumb M., Perry J. [et al.] Selective inactivation of vitamin B12 in rats by nitrous oxide. Lancet. 1978;2(8098):1023-1024.
64. Koblin D. D., Waskell L., Watson J. E., Stokstaed L. R., Eger E. I. Nitrous oxide inactivates methionine synthetase in human liver. Anesth. Analg. 1982;61:75-78.
65. Perry J., Deacon R., Lumb M. [et al.] The effect of nitrous oxide-induced inactivation of vitamin B12 on the activity of formyl-methenyl-methylenetetrahydrofolate synthetase, methylene-tetrahydrofolate reductase and formaminotetrahydrofolate transferase. Biochem. Biophys. Res. Commun. 1980; 97:1329-1333.
66. Nagele P., Tallchief D., Blood J. [et al.] Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth. Analg. 2011; 113:843-848.
67. Badner N. H., Drader K., Freeman D. [et al.] The use of intraoperative nitrous oxide leads to postoperative increases in plasma homocysteine. Anesth. Analg. 1998;87:711-713.
68. Ermens A. A., Refsum H., Rupreht J. [et al.] Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine. Clin. Pharmacol. Ther. 1991;49:385-393.
69. Badner N. H., Freeman D., Spence J. D. Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases. Anesth. Analg. 2001;93:1507-1510.
70. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006;5:949-960.
71. Sharer N. M., Nunn J. F., Royston J. P., Chanarin I. Effects of chronic exposure to nitrous oxide on methionine synthase activity. Br. J. Anaesth. 1983;55:693-701.
72. Sweeney B., Bingham R. M., Amos R. J. [et al.] Toxicity of bone arrow in dentists exposed to nitrous oxide. Br. Med. J. 1985;291:567-569.
73. Kondo H., Osborne M. L., Kolhouse J. F. [et al.] Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats. J. Clin. Invest. 1981;67:1270-1283.
74. Deacon R., Lumb M., Perry J. [et al.] Inactivation of methionine synthase by nitrous oxide. Eur. J. Biochem. 1980;104:419-423.
75. Molloy A. M., Orsi B., Kennedy D. G., Kennedy S., Weir D. G., Scott J. M. The relation- ship between the activity of methionine syn- thase and the ratio of S-adenosylmethionine to S-adenosyl-homocysteine in the brain and other tissues of the pig. Biochem. Pharmacol. 1992;44:1349-1355.
76. Koblin D. D., Watson J. E., Deady J. E. [et al.] Inactivation of methionine synthetase by nitrous oxide in mice. Anesthesiology. 1981;54:318-324.
77. Riedel B., Fiskerstrand T., Refsum H., Ueland P. M. Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase. Biochem. J. 1999;341:133-138.
78. Koblin D. D., Waskell L., Watson J. E. [et al.] Nitrous oxide inactivates methionine synthetase in human liver. Anesth. Analg. 1982; 61:75-78.
79. Royston B. D., Nunn J. F., Weinbren H. K., Royston D., Cormack R. S. Rate of inactivation of human and rodent hepatic methionine synthase by nitrous oxide. Anesthesiology. 1988;68:213-216.
80. Gutmann L., Johnsen D. Nitrous oxide-induced myeloneuropathy: report of cases. J. Am. Dent. Assoc. 1981;103:239-241.
81. Lunsford J. M., Wynn M. H., Kwan W. H. Nitrous oxide-induced myeloneuropathy. J. Foot Surg. 1983; 22:222-225.
82. Iwata K., O’Keefe G. B., Karanas A. Neurologic problems associated with chronic nitrous oxide abuse in a non-healthcare worker. Am. J. Med. Sci. 2001; 322:173-174.
83. Skacel P. O., Hewlett A. M., Lewis J. D. [et al.] Studies on the haemopoietic toxicity of nitrous oxide in man. Br. J. Haematol. 1983;53:189-200.
84. Culley D. J., Raghavan S. V., Waly M., Baxter M. G., Yukhananov R., Deth R. C., Crosby G. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesth. Analg. 2007;105:83-88.
85. El Otamni H., Moutawakil B., Moutawakil F., Gam I., Rafai M. A., Slassi I. Post-operative dementia: toxicity of nitrous oxide. Encephale. 2007;33:95–7.
86. Cousaert C., Heylens G., Audenaert K. Laughing gas abuse is no joke. An overview of the implications for psychiatric practice. Clin. Neurol. Neurosurg. 2013;115:859-862.
87. Tym M. K., Alexander J. Nitrous oxide induced manic relapse. Aust. N. Z. J. Psychiatry. 2011;45:1002.
88. Brodsky L., Zuniga J. Nitrous oxide: a psychotogenic agent. Compr. Psychiatry. 1975;16:185-188.
89. Wong S. L., Harrison R., Mattman A. [et al.] Nitrous Oxide (N2O)-Induced Acute Psychosis. Can. J. Neurol. Sci. 2014;41:672-674.
90. Kaufman E., Galili D., Furer R., Steiner J. Sensory experience induced by nitrous oxide analgesia. Anesth. Prog. 1990;37:282-285.
91. Brett A. Myeloneuropathy from whipped cream bulbs presenting as conversion disorder. Aust. N. Z. J. Psychiatry. 1997;31:131-132.
92. Block R. I., Ghoneim M. M., Kumar V., Pathak D. Psychedelic effects of a subanesthetic concentration of nitrous oxide. Anesth. Prog. 1990;37:271-276.
93. Dohrn C. S., Lichtor J. L., Coalson D. W. [et al.] Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug Alcohol. Depend. 1993;31:265-280.
94. Dohrn C. S., Lichtor J. L., Finn R. S. [et al.] Subjective and psychomotor effects of nitrous oxide in healthy volunteers. Behav. Pharmacol. 1992;3:19-30.
95. Layzer R. B., Fishman R. A., Schafer J. A. Neuropathy following abuse of nitrous oxide. Neurology. 1978;28:504-506.
96. Layzer R. B. Myeloneuropathy after prolonged exposure to nitrous oxide. Lancet. 1978;2:1227-1230.
97. Cohen E. N., Gift H. C., Brown B. W. [et al.] Occupational disease in dentistry and chronic exposure to trace anesthetic gases. J. Am. Dent. Assoc. 1980;101:21-31.
98. Brodsky J. B., Cohen E. N., Brown B. W. Jr. [et al.] Exposure to nitrous oxide and neurologic disease among dental professionals. Anesth. Analg. 1981;60:297-301.
99. Kripke B. J., Talarico L., Shah N. K. [et al.] Hematologic reaction to prolonged exposure to nitrous oxide. Anesthesiology. 1977;47:342-348.
100. Blanco G., Peters H. A. Myeloneuropathy and macrocytosis associated with nitrous oxide abuse. Arch. Neurol. 1983;40:416-418.
101. Hayden P. J., Hartemink R. J., Nicholson G. A. Myeloneuropathy due to nitrous oxide. Burns Incl. Therm. Inj. 1983;9:267-270.
102. Ogundipe O., Pearson M. W., Slater N. G. [et al.] Sickle cell disease and nitrous oxide-induced neuropathy. Clin. Lab. Haematol. 1999;21:409-412.
103. Felmet K., Robins B., Tilford D. [et al.] Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide. J. Pediatr. 2000;137:427-428.
104. Rosener M., Dichgans J. Severe combined degeneration of the spinal cord after nitrous oxide anaesthesia in a vegetarian. J. Neurol. Neurosurg. Psychiatry. 1996;60:354.
105. Lumb M., Perry J., Deacon R. [et al.] Changes in plasma folate levels in rats inhaling nitrous oxide. Scand. J. Haematol. 1981;26:61-64.
106. Weir D. G., Keating S., Molloy A. [et al.] Methylation deficiency causes vitamin B12-associated neuropathy in the pig. J. Neurochem. 1988;51:1949-1952.
107. McNeely J. K., Buczulinski B., Rosner D. R. Severe neurological impairment in an infant after nitrous oxide anesthesia. Anesthesiology. 2000;93:1549-1550.
108. Timms S. R., Cure J. K., Kurent J. E. Subacute combined degeneration of the spinal cord: MR findings. AJNR Am. J. Neuroradiol. 1993;14:1224-1227.
109. Renard D., Dutray A., Remy A., Castelnovo G., Labauge P. Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Neurol. Sci. 2009;30:75-76.
110. Singer M. A., Lazaridis C., Nations S. P., Wolfe G. I. Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review. Muscle Nerve. 2008;37:125-129.
111. Somyreddy K., Kothari M. Nitrous oxide induced sub-acute combined degeneration of spinal cord: a case report. Electromyogr. Clin. Neurophysiol. 2008;48:225-228.
112. Wijesekera N. T., Davagnanam I., Miszkiel K. Subacute combined cord degeneration: a rare complication of nitrous oxide misuse. A case report. Neuroradiol. J. 2009;22:194-197.
113. Renard D., Dutray A., Remy A., Castelnovo G., Labauge P. Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Neurol. Sci. 2009;30:75-76.
114. Hadzic A., Glab K., Sanborn K. V., Thys D. M. Severe neurologic deficit after nitrous oxide anesthesia. Anesthesiology. 1995;83:863-866.
115. Holloway K. L., Alberico A. M. Postoperative myeloneuropathy: a preventable complication in patients with B12 deficiency. J. Neurosurg. 1990;72:732-736.
116. Marié R. M., Le Biez E., Busson P. [et al.] Nitrous oxide anesthesia-associated myelopathy. Arch. Neurol. 2000; 57:380-382.
117. Girón J. M., Muñoz A., Caro P. [et al.] Anesthesia paresthetica: contribution of a new case and evolutive study using magnetic resonance. Neurologia. 1998;13:307-310.
118. Sesso R. M., Iunes Y., Melo A. C. Myeloneuropathy following nitrous oxide anesthaesia in a patient with macrocytic anaemia. Neuroradiology. 1999;41:588-590.
119. Ahn S. C., Brown A. W. Cobalamin deficiency and subacute combined degeneration after nitrous oxide anesthesia: a case report. Arch. Phys. Med. Rehabil. 2005;86:150-153.
120. Marie R. M., Le Biez E., Busson P. [et al.] Nitrous oxide anesthesia-associated myelopathy. Arch. Neurol. 2000;57:380-382.
121. Schilling R. F. Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects. JAMA. 1986;255:1605-1606.
122. Massey T. H., Pickersgill T. T., J Peall K. Nitrous oxide misuse and vitamin B12 deficiency. BMJ Case Rep. 2016 May 31;2016.
123. Buizert A., Sharma R., Koppen H. When the Laughing Stops: Subacute Combined Spinal Cord Degeneration Caused by Laughing Gas Use. J Addict Med. 2017 Feb 3.
124. Sleeman I., Wiblin L., Burn D. An unusual cause of falls in a young woman. J. R. Coll. Physicians Edinb. 2016;46:160-162.
125. Morris N., Lynch K., Greenberg S. A. Severe motor neuropathy or neuronopathy due to nitrous oxide toxicity after correction of vitamin B12 deficiency. Muscle Nerve. 2015;51:614-616.
126. Ghobrial G. M., Dalyai R., Flanders A. E. [et al.] Nitrous oxide myelopathy posing as spinal cord injury. J. Neurosurg. Spine. 2012;16:489-491.
127. Kinsella L. J., Green R. ‘Anesthesia paresthetica’: nitrous oxide-induced cobalamin deficiency. Neurology. 1995;45:1608-1610.
128. Stacy C. B., Di Rocco A., Gould R. J. Methionine in the treatment of nitrous-oxide-induced neuropathy and myeloneuropathy. J. Neurol. 1992;239:401-403.
129. Shimizu T., Nishimura Y., Fujishima Y. [et al.] Subacute myeloneuropathy after abuse of nitrous oxide: an electron microscopic study on the peripheral nerve. Rinsho Shinkeigaku. 1989;29:1129-1135.
130. Scott J. M., Dinn J. J., Wilson P. [et al.] Pathogenesis of subacute combined degeneration: A result of methyl group deficiency. Lancet. 1981;2:334-337.
131. Selzer R. R., Rosenblatt D. S., Laxova R. [et al.] Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase deficiency. N. Engl. J. Med. 2003;349:45-50.
132. Lassen H. C. A., Henricksen E., Neukirch F. [et al.] Treatment of tetanus. Severe bone-marrow depression after prolonged nitrous-oxide anesthesia. Lancet. 1956;1:527-530.
133. Green C. D., Eastwood D. W. Effects of nitrous oxide inhalation on hemopoiesis in rats. Anesthesiology. 1963;24:341-345.
134. O’Sullivan H., Jennings F., Ward K. [et al.] Human bone marrow biochemical function and megaloblastic hematopoiesis after nitrous oxide anesthesia. Anesthesiology. 1981;55:645-649.
135. Brodsky J. B., Cohen E. N., Brown B. W. [et al.] Exposure to nitrous oxide and neurologic disease among dental professionals. Anesth. Analg. 1981;60:297-301.
136. Nunn J. F. Clinical aspects of the interaction between nitrous oxide and vitamin B12. Br. J. Anaesth. 1987;59:3-13.
137. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006;5:949-960.
138. Trivette E. T., Hoedebecke K., Berry-Cabán C. S. [et al.] Megaloblastic hematopoiesis in a 20 year old pregnant female. Am. J. Case Rep. 2013;14:10-12.
139. Andres E., Loukili N. H., Noel E. [et al.] Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171:251-259.
140. Parbrook G. D. Leucopenic effects of prolonged nitrous oxide treatment. Br. J. Anaesth. 1967;39:119-127.
141. Amess J. A. L., Burman J. F., Rees G. M. [et al.] Megaloblastic haemopoiesis in patients receiving nitrous oxide. Lancet. 1978;2:339-342.
142. Sanders R. D. B., Weimann J., Maze M. Biologic effects of nitrous oxide: A mechanistic and toxicologic review. Anesthesiology. 2008;109:707-722.
143. Luhmann J. D., Kennedy R. M. Nitrous oxide in the pediatric emergency department. Clin. Pediatr. Emerg. Med. 2000;1:285-289.
144. Yagiela J. A. Health hazards and nitrous oxide: a time for reappraisal. Anesth. Prog.1991; 38:1-11.
145. Alhborg J. R., Axelsson G., Bodin L. Nitrous oxide exposure and subfertility among Swedish midwives. Int. J. Epidemiol. 1996;25:783-90.
146. Maze M. J., Fujinaga M. Recent advances in understanding the actions and toxicity of nitrous oxide. Anaesthesia. 2000;55:311–314.
147. Doran M., Rassam S. S., Jones L. M. [et al.] Toxicity after intermittent inhalation of nitrous oxide for analgesia. BMJ. 2004;328:1364-1365.
148. Faguer S., Ruiz J., Mari A. Massive hyperhomocysteinaemia as a complication of nitrous oxide inhalation. Br. J. Clin. Pharmacol. 2016;81:391-392.
149. Mayer E. L., Jacobsen D. W., Robinson K. Homocysteine and coronary atherosclerosis. J. Am. Coll. Cardiol. 1996;27:517-527.
150. Graham I. M., Daly L. E., Refsum H. M. [et al.] Plasma homocysteine as a risk factor for vascular disease. JAMA. 1997; 277:1775-1781.
151. Indraratna P., Alexopoulos C., Celermajer D., Alford K. Acute ST-Elevation Myocardial Infarction, a Unique Complication of Recreational Nitrous Oxide Use. Heart Lung Circ. 2017 Mar 6 pit: S1443-9506(17)30084-7
152. Nygard O., Nordrehaug J. E., Refsum H. [et al.] Plasma homocysteine levels and mortality in patients with coronary artery disease. N. Engl. J. Med. 1997;337:230-236.
153. Badner N. H., Beattie W. S., Freeman D. [et al.] Nitrous oxide-induced increased homocysteine concentrations are associated with increased postoperative myocardial ischemia in patients undergoing carotid endarterectomy. Anesth. Analg. 2000;91:1073-1079.
154. Booij L. H. Dj. Neurotoxicity caused by anesthetics in pediatric anesthesia. Medical News of North Caucasus. 2016;11(2):231-235. doi:10.14300/mnnc.2016.11048
155. Jevtovic-Todorovic V., Hartman R. E., Izumi Y. [et al.] Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J. Neurosci. 2003;23:876-882.
156. Lu L. X., Yon J. H., Carter L. B. [et al.] General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Apoptosis. 2006;11:1603-1615.
157. Jevtovic-Todorovic V., Hartman R. E., Izumi Y. [et al.] Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J. Neurosci. 2003;23:876-882.
158. Shu Y., Patel S. M., Pac-Soo C. [et al.] Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Anesthesiology. 2010;113:360-368.
159. Zou X., Liu F., Zhang X., Patterson T. A. [et al.] Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey. Neurotoxicol. Teratol. 2011;33:592-597.
160. Hollmen A. I., Jouppila R., Koivisto M. [et al.] Neurologic activity of infants following anesthesia for cesarean section. Anesthesiology. 1978;48:350-356.

Keywords: pediatric anesthesia, children surgery, anesthesia associated complications in children, drugs adverse reactions


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy