Medical news
of the North Caucasus
Scientific journal
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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A case of familial thrombophilia in the patient with complicated peripartum cardiomyopathy

[Notes from practice]
Alexandr Yagoda; Natalia Gladkikh; Ilona Znamenskaya; Madina Dereva; Sergey Yagoda;

Peripartum cardiomyopathy is a thrombophilia-associated disease, which manifests with severe heart failure and reduced left ventricular ejection fraction in patients without pre-existing cardiac pathology, usually 1 month before or after the delivery. Clinical observations suggest possible role of underlying congenital thrombophilia in the development of thromboembolism and formation of severe heart systolic dysfunction in patients with peripartum cardiomyopathy. We presented a clinical case of multiple biventricular thrombi in 28-year-old primigravida with peripartum cardiomyopathy and genetic traits of hereditary thrombophilia, which resulted in the recovery of heart contractile function. In conclusion, we discussed common genetic polymorphisms to investigate the link between the hereditary thrombophilia and peripartum cardiomyopathy.


1. Bultmann B. D., Klingel K., Nabauer M., Wallwiener D., Kandolf R. High prevalence of viral genomes and inflammation in peripartum cardiomyopathy. Am. J. Obstet Gynecol. 2005;193:363-365. doi: 10.1016/j.ajog.2005.01.022
2. Elkayam U., Akhter M. W., Singh H., Khan S., Bitar F. [et al.] Pregnancy-associated cardiomyopathy: clinical characteristics and a comparison between early and late presentation. Circulation. 2005;111:2050-2055. doi:10.1161/01.CIR.0000162478.36652.7E
3. Goland S., Modi K., Bitar F., Janmohamed M., Mirocha J. M. [et al.] Clinical profile and predictors of complications in peripartum cardiomyopathy. J. Card. Fail. 2009;15:645-650. doi: 10.1016/j.cardfail.2009.03.008
4. Lane D. A., Grant P. J. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood. 2000;95(5):1517-1532.
5. Morales A., Painter T., Siegfried J. D., Li D., Norton N. [et al.] Rare variant mutations in pregnancyassociated or peripartum cardiomyopathy. Circulation. 2010;121:2176-2182. doi: 10.1161/CIRCULATIONAHA.109.931220
6. Ntusi N. B., Mayosi B. M. Aetiology and risk factors of peripartum cardiomyopathy: a systematic review. Int. J. Cardiol. 2009;131:168-179. doi: 10.1016/j.ijcard.2008.06.054
7. Sakamoto A., Hosoya N., Kageyama S., Yoshizaki T., Takeuchi R. [et al.] Peripartum cardiomyopathy with biventricular thrombus which led to massive cerebral embolism. J. Cardiology Cases. 2014;9:71-74.
8. Sliwa K., Fett J., Elkayam U. Peripartum cardiomyopathy. Lancet. 2006;368:687-693. doi: 10.1016/S0140-6736(06)69253-2
9. Torabi R., Zarei S., Zeraati H., Akhondi M. M., Hadavi R. [et al.] Combination of thrombophilic gene polymorphisms as a cause of increased the risk of recurrent pregnancy loss. J. Reproduct. Infertil. 2012;13:89-94.
10. Yagoda A., Gladkikh N., Gasparyan N., Koroy P., Septa I. A clinical case of recurrent peripartum cardiomyopathy complicated by intracardiac thrombosis. Medical News of North Caucasus. 2012;2(26):93-96.
11. Yamada N., Arinami T., Yamakawa-Kobayashi K., Watanabe H., Sohda S. [et al.] The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia. J. Hum. Genet. 2000;45:138-141. doi:10.1007/s100380050

Keywords: pregnancy, thrombophilia, cardiomyopathies, embolism and thromboses

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy