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Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
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A case of familial thrombophilia in the patient with complicated peripartum cardiomyopathy

[Notes from practice]
Alexandr Yagoda; Natalia Gladkikh; Ilona Znamenskaya; Madina Dereva; Sergey Yagoda;

Peripartum cardiomyopathy is a thrombophilia-associated disease, which manifests with severe heart failure and reduced left ventricular ejection fraction in patients without pre-existing cardiac pathology, usually 1 month before or after the delivery. Clinical observations suggest possible role of underlying congenital thrombophilia in the development of thromboembolism and formation of severe heart systolic dysfunction in patients with peripartum cardiomyopathy. We presented a clinical case of multiple biventricular thrombi in 28-year-old primigravida with peripartum cardiomyopathy and genetic traits of hereditary thrombophilia, which resulted in the recovery of heart contractile function. In conclusion, we discussed common genetic polymorphisms to investigate the link between the hereditary thrombophilia and peripartum cardiomyopathy.

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Keywords: pregnancy, thrombophilia, cardiomyopathies, embolism and thromboses


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Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy