Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


Polymorphic variants of the TLR 2 gene in syphilis

Lyudmila Barycheva; Milana Minasyan; Vyacheslav Chebotarev; Alexey Odinets;

Immunogenetic studies were performed in 100 people with syphilitic infection of the East Slavic population of the Southern region of Russia. It has been established that genotypic variants of 753 Arg/Gln and 753 Gln/Gln, as well as the presence of Gln/753 allele, are molecular-genetic markers of increased risk of syphilis development.


1. Petruccioli E., Scriba J. T., Petrone L., Hatherill M., Cirillo D. M. [et al.] Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis. European Respiratory Journal. 2016;48:1751-1763. doi:10.1183/13993003.01012-2016
2. Medvedev A. E. Receptor Polymorphisms, Inflammatory and Infectious Diseases, Allergies, and Cancer J. Interferon Cytokine Res. 2013;33(9):467-484. doi: 10.1089/jir.2012.0140
3. Biyikli O. O., Baysak A., Ece G., Oz A. T., Ozhan M. H. [et al.] Role of Toll-Like Receptors in Tuberculosis Infection. Jundishapur J. Microbiol. 2016;9(10):e20224. Published: Oct 2016. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136443/. doi: 10.5812/jjm.20224
4. Ahmad-Nejad P., Denz C., Zimmer W., Wacker J., Bugert P. [et al.] The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis. Genet. Test Mol. Biomarkers. 2011;15:645-651. doi: 10.1089/gtmb.2010.0258
5. Bustamante J., Tamayo E., Flórez S., Telleria J. J., Bustamante E. [et al.] Toll-like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis. Rev. Esp. Cardiol. 2011;64(11):1056-1059. doi: 10.1016/j.rec.2011.02.027

Keywords: syphilis, gene polymorphism, receptors of innate immunity

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy