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ISSN 2073-8137

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Acute poisoning with antihypertensive and antiarrhythmic medicines - clinicoepidemiological study

[Internal diseases]
Rayna Stoyanova; Julia Radenkova – Saeva;

The characteristics of acute poisoning with antihypertensive and antiarrhythmic medicines were investigated in the retrospective epidemiological study. All cases of antihypertensive and antiarrhythmic medicines (AAM) poisoning were analyzed for 3 years period. Demographic data, previous illness were obtained retrospectively. The cases of poisonings were evaluated with respect to clinical course, therapy and outcome. 896 patients with acute exogenous intoxications were treated. 136 cases (15.2 %) of them were poisoning with AAM – beta-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, etc. 95 (69.9 %) were female and 41 (30.1 %) male, between the ages of 18 and 98. 61 individuals (44.9 %) were poisoned by only one drug. In 75 (55.1 %) remaining cases, intoxications were mixed, including other different medications or psychoactive substances. 112 cases (86.8 %) were intentional – a result of a suicide attempt. The severity of poisonings varied from moderate to extremely severe. In 17 patients poisoning occurs with the signs of exotoxic shock, 3 of them – with fatal outcome. In the examined group three patients died of cardiogenic shock and secondary acute respiratory failure resistant to therapy. In conclusion, patients with acute poisoning from AAM were a large proportion of all patients, received acute poisoning and represent a serious challenge for the physician – toxicologist.


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Keywords: acute poisoning, antihypertensive, antiarrhythmics medicines

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy