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ISSN 2073-8137

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Chronopharmacology of lithium preparations

Eduard Arushanyan;

As shown by modern literature data, the time factor plays an important role in the pharmacodynamics of lithium used for the treatment of bipolar affective disorder (BAD). Its chronotropic properties may depend on the effect on the function of suprachiasmatic nuclei of the hypothalamus, as well as inhibition of glycogen synthase-3 kinase and the mobilization of the epiphyseal hormone melatonin.


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Keywords: lithium, bipolar affective disorder, melatonin

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy