of the North Caucasus
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Study of hepatotoxicity of niosomal form of doxorubicin
[Pharmacology]
Igor Bazikov; Eduard Beyer; Alexander Maltsev; Ekaterina Goptareva; Natalia Malinina; Valentina Botasheva; Svetlana Dushko;
The study of chronic toxicity of the niosomal form of doxorubicin when administered systemically to a maximum dose of 2.6 mg/kg has a moderate hepatotoxicity, which was manifested in the cytolytic syndrome and in violation of hematopoiesis and hemostasis parameters. Reducing the dose of niosomal form of doxorubicin to 1.6–2.0 mg/kg did not cause changes in hematological, biochemical and pathological parameters of laboratory animals.
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Keywords: niosomes, doxorubicin, hepatotoxic effects, cytolytic syndrome
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy