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https://doi.org/10.14300/mnnc.2016.11066

Cytokine regulation and autoimmunity features in patients with joint hypermobility syndrome

[CTD in adults]
Galina Saneeva;

The article presents the results of the study of bone cytokines indicators, hormones of bone metabolism and the levels of thyroid autoantibodies and autoantibodies to type-specific collagens in 146 patients with joint hypermobility syndrome (JHS). The prevalence of vitamin D deficiency was significantly higher in patients with JHS compared to the control. The deviations of the bone mediators ratio in patients with JHS were identified. The study has demonstrated the increased incidence of autoimmune thyroiditis in patients with JHS and significantly more frequent existence of antithyroid antibodies and the antibodies to I-II types collagen.

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Keywords: joint hypermobility syndrome, bone remodeling, cytokines, autoimmunity, collagen