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ISSN 2073-8137
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Adhesion molecules: contribution to formation of dysplastic phenotype

[Internal diseases]
Alexandr Yagoda; Lubov Gladkih; Natalia Gladkikh;

Interrelation between the plasma levels of selectins (E, L, P), intercellular (ICAM-1), platelet-endothelial (PECAM-1), and vascular (VCAM-1) cell adhesion molecules and peculiar features of phenotype was determined in 102 patients (79 men and 23 women, aged 21.9±4.4 years) with signs of connective tissue dysplasia (CTD). Mitral valve prolapse syndrome was revealed in 88 patients, benign hypermobility of joints – in 2, unclassified phenotype – in 3, and increased dysplastic stigmatization – in 9 patients. The score of systemic involvement of connective tissue was 2.0 [1.0-3.0] points. The patients with CTD were characterized by increased E-selectin, ICAM-1, VCAM-1, and decreased PECAM-1. Maximal concentrations of E-selectin and VCAM-1 were determined in cases of classified syndrome/phenotype; E-selectine, ICAM-1, and VCAM-1 – in hemodynamic mitral valve prolapse; ICAM-1 – in patients with great number of minor heart anomalies. External and visceral dysplastic signs could be used as screening-stratification factors of disbalance of adhesion molecules. Disorders of intercellular connection may be used for revealed subclinical endothelial dysfunction and formed groups of cardiovascular complications.

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Keywords: adhesion molecules, connective tissue, dysplasia, phenotype


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