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https://doi.org/10.14300/mnnc.2026.00020

Specific features of mycoplasma infection course under increasing antibiotic resistance

[Reviews]
Ирина Ивановна Olshanskaya; Vladimir Baturin;

This review covers key aspects of the pathogenesis, clinical manifestations, and diagnostic methods for Mycoplasma infection. There are typical pulmonary presentations and their complications described, alongside extrapulmonary manifestations affecting various organs and systems. Special emphasis is placed on the diverse mechanisms of resistance development, also highlighting the critical role of bacteriological diagnostics and antimicrobial susceptibility testing. The study addresses clinical epidemiology and the prevalence of Mycoplasma infection in both adult and pediatric populations. Immunological considerations involve treatment strategies and the potential for immunoprophylaxis, as prolonged pathogen persistence leads to cytotoxic effects and subsequent autoimmune-mediated organ damage and immunosuppression.

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Keywords: mycoplasma, pneumonia, extrapulmonary manifestations, antibiotic resistance, epidemiology, immunity, autoimmune processes