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https://doi.org/10.14300/mnnc.2025.20078

Innate immunity defects in the pediatric cohort of the Stavropol Region

[Abstracts]
Natalia Alexandrovna Kozmova; Lyudmila Barycheva; Milana Minasyan; Vera Valentinovna Kuznetsova; Alina Vladimirovna Golubeva; Kristina Arturovna Apaguni;

The study implied a prospective observational study involving 65 patients featuring innate immune defects. 87.7 % of the children had severe episodes of infections, while 53.8 % had somatic diseases with multiple organ damage. 38.5 % of the children received replacement therapy, with another 20 % given hematopoietic cell transplantation. Compared to healthy respondents, patients with primary immunodeficiencies were found to have a statistically significant decrease in the overall life-quality score, as well as in the scores reflecting their physical, emotional, social well-being, and academic performance.

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References:
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Keywords: innate immune defects, quality of life, children