• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2025.20054

Role of free-radical processes in development of periodontitis infected with antibiotic-resistant strains of Staphylococcus aureus in experiment

[Stomatology]
Igor Bazikov; Victor Mazharov; Alexander Maltsev; Valentina Botasheva; Elena Diskaeva; Anna Efremenko;

The study focused on the role of free-radical processes in the development of periodontitis infected with antibiotic-resistant strains of Staphylococcus aureus. At the initial stages of periodontitis, a high level of superoxide anion was detected, which triggers a cascade of biochemical processes and leads to activated cellular immunity. A study of the dynamics pertaining to the changes in the content of beta-defensin in periodontal tissues during the inflammatory process caused by infection with antibiotic-resistant strains of Staphylococcus aureus showed that from the beginning of the experiment until Day 20, the content of beta-defensin in the inflammation focus went up significantly. This dynamic correlated with superoxidanion formation in the focus of inflammation, and with histological changes when the periodontal tissue was infected.

Download

References:
1. Tikhomirova E. A., Dro- nozhnev E. U., Atrushkevich V. G. β-defensins and inflammatory periodontal disease: a systematic review. Parodontologiya. – Parodontology. 2020;25(4):276-286. (In Russ.). https://doi.org/10.33925/1683-3759-2020-25-4-276-286
2. Prechlyuk O. A., Zhadko S. I., Romanenko I. G., Prechlyuk A. Ya., Kriventsov M. A. Effects of omega-3 fatty acids in a combined experimental model of periodontitis and metabolic syndrome. Parodontologiya – Parodontology. 2024;29(3):246-257. (In Russ.). https://doi.org/10.33925/1683-3759-2024-978
3. Oz H. S., Puleo D. A. Animal models for periodontal disease. J. Biomed. Biotechnol. 2011;2011:754857. https://doi.org/10.1155/2011/754857
4. Gurusamy K. S., Koti R., Toon C. D., Wilson P., Davidson B. R. (August 2013). Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds. The Cochrane Database of Systematic Reviews (8): CD009726. https://doi.org/10.1002/14651858.CD009726.pub2
5. Ayala A., Munoz M. F., Arguelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid. Med. Cell. Longev. 2014;2014:360438. https://doi.org/10.1155/2014/360438
6. Maltsev A. N., Bazikov I. A., Rubailo M. V., Sedykh O. I., Efremenko A. A. Repeatability indicators of the results of determining the quantitative content of defensins obtained by ELISA and HPLC methods // Biotechnology: A look into the future: collection. Stavropol: StGMU, 2021:68-71. (In Russ.).
7. Dadar M., Shahali Y., Chakraborty S., Prasad M., Tahoori F. [et al.]. Antiinflammatory peptides: current knowledge and promising prospects. Inflamm. Res. 2019;68(2):125-145. https://doi.org/10.1007/s00011-018-1208-x
8. Loffredo L., Violi F. COVID-19 and cardiovascular injury: A role for oxidative stress and antioxidant treatment? Int. J. Cardiol. 2020;312:136. https://doi.org/10.1016/j.ijcard.2020.04.066
9. Domka K., Goral A., Firczuk M. cROSsing the Line: Between Beneficial and Harmful Effects of Reactive Oxygen Species in B-Cell Malignancies. Front. Immunol. 2020;11:1538. https://doi.org/10.3389/fimmu.2020.01538
10. Sies H. Oxidative stress: concept and some practical aspects. Antioxidants (Basel). 2020;9:852. https://doi.org/10.3390/antiox9090852
11. Jourdain M.-L., Velard F., Pierrard L., Sergheraert J., Gangloff S. C. [et al.]. Cationic antimicrobial peptides and periodontal physiopathology: A systematic review. J. Periodontal. Res. 2019;54(6):589-600. https://doi.org/10.1111/jre.12676
12. Özdemir M., Caglayan F., Bikker F. J., Pussinen P., Könönen E. [et al.]. Gingival tissue human beta-defensin levels in relation to infection and inflammation. J. Clin. Periodontol. 2020;47(3):309-318. https://doi.org/10.1111/jcpe.13227

Keywords: β-defensin, periodontitis, inflammation, antibiotic resistance