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Certain genetic markers indicating severe alcoholic hepatitis
[Abstracts]
Natalya Geyvandova; Bolbat Geogiy Konstantinovich; Ilona Znamenskaya; Alexandr Yagoda;
The study implied examination of thirty-nine patients with alcoholic liver disease (ALD): 28 males and 11 females aged 45.4±9.3. Severe alcoholic hepatitis (SAH) was diagnosed in 27 patients (the main group), with another 12 patients diagnosed with liver steatosis (the comparison group). SAH developed in 16 patients against the background of cirrhosis of the liver and in 11 patients without cirrhotic transformation of the liver. The genetic polymorphisms Arg47His in the ADH1B gene, Glu504Lys in the ALDH2 gene, and G-1293C (c1/c2) in the CYP2E1 gene were determined by PCR analysis using a kit of Litech reagents. The distribution of ADH1B (Arg47His) polymorphisms did not differ between the groups (p>0.05). ALDH2 (Glu504Lys) polymorphism was not detected in any patient. The CYP2E1 c1/c2 genotype and c2 allele were significantly more common in SAH (22 % vs 7 %, p=0.032; 12 % vs 3 %, p=0.036, respectively). In addition, there was a tendency for CYP2E1 c1/c2 to be associated with a severe course (MDF>32). Thus, the obtained results confirm the significance of CYP2E1 polymorphism in the pathogenesis of SAH, which may be important for risk stratification.
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Keywords: alcoholic hepatitis, liver steatosis, alcohol-metabolizing enzymes, genetic polymorphisms
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy