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EBSCO

https://doi.org/10.14300/mnnc.2025.20014

A clinical case of Dupuytren’s disease in monozygotic twins

[Notes from practice]
Viktor Shamik; Alexey Leonidovich Elfimov; Vladimir Eduardovich Rostorguev; Pavel Viktorovich Shamik; Arsen Avedikovich Tokhtamishyan;

The item presents a clinical observation of Dupuytren’s disease manifestation in homozygous twins. Both patients developed the first signs of the disease at the age of 30–40. In one of them, the injured tendon apparatus in the forearm triggered the disease progression, requiring surgical intervention. Selective fasciectomy was performed on the patient aged over 60 years, with good outcomes obtained within a remote postoperative period. In view of this, the manifestation of the disease in homozygous twins serves proof to the fact that Dupuytren’s disease has a significant hereditary component as well as an overall heritability going up to 80 %.

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References:
1. Rodrigues J. N., Becker G. W., Ball C., Zhang W., Giele H. [et al.]. Surgery for Dupuytren’s contracture of the fingers. Cochrane Database of Systematic Reviews. 2015;12:CD010143. https://doi.org/10.1002/14651858.CD010143.pub2
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5. Zhigalo A. V., Morozov V. V., Pochtenko V. V., Chevardina M. A. Modern approach to classification of Dupuytren disease. Voprosy rekonstruktivnoj I plasticheskoj hirurgii. – Issues of reconstructive and plastic surgery. 2018;2(65):50-61. (In Russ.). https://doi.org/10.17223/1814147/65/07

Keywords: Dupuytren’s disease, homozygous twins, selective fasciectomy