Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
[Reviews]
Irina Vishlova; Anastasia Igorevna Raevskaya; Marina Vladimirovna Ponomareva; Markha Khamzatovna Sukisheva; Dany Bulatovich, Khurtsaev; Lyubov Valerievna Shtemberg; Olga Aleksandrovna Soboleva; Aza Beslanovna Barkinkhoeva;
Over 69 million people are diagnosed with traumatic brain injury annually, whereas the issue itself is associated with a number of complications, epilepsy being one of them. The risk of post-traumatic epilepsy development falls within the range of 2 % to 50 % depending on the injury location and severity. This article presents a discussion focusing on the main issues of etiopathogenesis, diagnostics specifics and treatment for post-traumatic epilepsy. The said discussion is based on an analysis of literary sources available both in Russian and in English embracing the period of 2013–2023, as well as on RSCI databases, and Pubmed.
References:
1. Ahmed S., Venigalla H., Mekala H. M., Dar S., Hassan M., Ayub S. Traumatic brain injury and neuropsychiatric complications. Indian J. Psychol. Med. 2017;39(2):114-121. https://doi.org/10.4103/0253-7176.203129
2. Keith K. A., Huang J. H. Animal models of post-traumatic epilepsy. Diagnostics (Basel). 2019;10(1):4. https://doi.org/10.3390/diagnostics10010004
3. Mariajoseph F. P., Rewell S. S., O’Brien T. J., Semple B. D., Antonic-Baker A. Incidence of post-traumatic epilepsy following paediatric traumatic brain injury: protocol for systematic review and meta-analysis. BMJ Open. 2021;11(11):e054034. https://doi.org/10.1136/bmjopen-2021-054034
4. Rauchman S. H., Zubair A., Jacob B., Rauchman D., Pinkhasov A., [et al.]. Traumatic brain injury: Mechanisms, manifestations, and visual sequelae. Front. Neurosci. 2023;17:1090672. https://doi.org/10.3389/fnins.2023.1090672
5. Saletti P. G., Ali I., Casillas-Espinosa P. M., Semple B. D., Lisgaras C. P. [et al.]. In search of antiepileptogenic treatments for post-traumatic epilepsy. Neurobiol. Dis. 2019;123:86-99. https://doi.org/10.1016/j.nbd.2018.06.017
6. Semple B. D., Zamani A., Rayner G., Shultz S. R., Jones N. C. Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy. Neurobiol. Dis. 2019;123:27-41. https://doi.org/10.1016/j.nbd.2018.07.018
7. Tubi M. A., Lutkenhoff E., Blanco M. B., McArthur D., Villablanca P. [et al.]. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study. Neurobiol. Dis. 2019;123:115-121. https://doi.org/10.1016/j.nbd.2018.05.014
8. Sharma R., Leung W. L., Zamani A., O’Brien T. J., Casillas Espinosa P. M., Semple B. D. Neuroinflammation in post-traumatic epilepsy: pathophysiology and tractable therapeutic targets. Brain Sci. 2019;9(11):318. https://doi.org/10.3390/brainsci9110318
9. Small C., Dagra A., Martinez M., Williams E., Lucke-Wold B. Examining the role of astrogliosis and JNK signaling in post-traumatic epilepsy. Egypt. J. Neurosurg. 2022;37:1. https://doi.org/10.1186/s41984-021-00141-x
10. Ngadimon I. W., Aledo-Serrano A., Arulsamy A., Mohan D., Khoo C. S. [et al.]. An interplay between post-traumatic epilepsy and associated cognitive decline: A systematic review. Front. Neurol. 2022;13:827571. https://doi.org/10.3389/fneur.2022.827571
11. Maslova N. N., Gorelov V. A. Pathogenesis and treatment of symptomatic post-traumatic epilepsy. Nevrologija, nejropsihistrija, psihosomatika. – Neurology, neuropsychistry, psychosomatics. 2014;12(4):271-278. (In Russ.).
12. Foresti M. L., Garzon E., Pinheiro C. C. G., Pacheco R. L., Riera R., Mello L. E. Biperiden for prevention of post-traumatic epilepsy: A protocol of a double-blinded placebo-controlled randomized clinical trial (BIPERIDEN trial). PLoS One. 2022;17(9):e0273584. https://doi.org/10.1371/journal.pone.0273584
13. Fordington S., Manford M. A review of seizures and epilepsy following traumatic brain injury. J. Neurol. 2020;267(10):3105-3111. https://doi.org/10.1007/s00415-020-09926-w
14. Karlander M., Ljungqvist J., Sörbo A., Zelano J. Risk and cause of death in post-traumatic epilepsy: a register-based retrospective cohort study. J. Neurol. 2022;269(11):6014-6020. https://doi.org/10.1007/s00415-022-11279-5
15. Dadas A., Janigro D. Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy. Neurobiol. Dis. 2019;123:20-26. https://doi.org/10.1016/j.nbd.2018.06.022
16. Gopalan H., P K., S A. Use of anti-epileptic drugs for post traumatic seizure: A global survey. Ann. Neurosci. 2023;30(1):26-32. https://doi.org/10.1177/09727531221120765
17. Xu T., Yu X., Ou S., Liu X., Yuan J. [et al.]. Risk factors for posttraumatic epilepsy: A systematic review and meta-analysis. Epilepsy Behav. 2017;67:1-6. https://doi.org/10.1016/j.yebeh.2016.10.026
18. Yeh C. C., Chen T. L., Hu C. J., Chiu W. T., Liao C. C. Risk of epilepsy after traumatic brain injury: a retrospective population-based cohort study. J. Neurol. Neurosurg. Psychiatry. 2013;84(4):441-445. https://doi.org/10.1136/jnnp-2012-302547
19. Hellwinkel J. E., Anderson F. L., Trofa D. P., Deitrich M. P., Dansby J. D. [et al.]. Post-traumatic epilepsy after sports-related concussion: A case report. Neurotrauma Rep. 2020;1(1):42-45. https://doi.org/10.1089/neur.2020.0013
20. Pugh M. J., Kennedy E., Gugger J. J., Mayo J., Tate D. [et al.]. The military injuries: understanding post-traumatic epilepsy study: understanding relationships among lifetime traumatic brain injury history, epilepsy, and quality of life. J. Neurotrauma. 2021;38(20):2841-2850. https://doi.org/10.1089/neu.2021.0015
21. Pease M., Gonzalez-Martinez J., Puccio A., Nwachuku E., Castellano J. F. [et al.]. Risk factors and incidence of epilepsy after severe traumatic brain injury. Ann. Neurol. 2022;92(4):663-669. https://doi.org/10.1002/ana.26443
22. Shishmanidi A. K., Karpov S. M., Vyshlova I. A., Karpov A. S., Bahadova E. M. Neurotrauma as a factor of epileptogenesis. Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova. – Journal of Neurology and Psychiatry. S. S. Korsakov. 2018;118(10):90-92. (In Russ.). https://doi.org/10.17116/jnevro201811810190
23. Fang M., Liu W., Tuo J., Liu M., Li F. [et al.]. Advances in understanding the pathogenesis of post-traumatic epilepsy: a literature review. Front. Neurol. 2023;14:1141434. https://doi.org/10.3389/fneur.2023.1141434
24. Santana-Gomez C. E., Medel-Matus J. S., Rundle B. K. Animal models of post-traumatic epilepsy and their neurobehavioral comorbidities. Seizure. 2021;90:9-16. https://doi.org/10.1016/j.seizure.2021.05.008
25. Mendonça G. S., Sander J. W. Post traumatic epilepsy: there is still much to learn. Arq. Neuropsiquiatr. 2019;77(6):373-374. https://doi.org/10.1590/0004-282X20190068
26. Khalili H., Kashkooli N. R., Niakan A., Asadi-Pooya A. A. Risk factors for post-traumatic epilepsy. Seizure. 2021;89:81-84. https://doi.org/10.1016/j.seizure.2021.05.004
27. Yu T., Liu X., Sun L., Lv R., Wu J., Wang Q. Predicting global functional outcomes among post-traumatic epilepsy patients after moderate-to-severe traumatic brain injury: development of a prognostic model. Front. Neurol. 2022;13:874491. https://doi.org/10.3389/fneur.2022.874491
28. Golub V. M., Reddy D. S. Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions. Pharmacol. Rev. 2022;74(2):387-438. https://doi.org/10.1124/pharmrev.121.000375
29. Pinggera D., Geiger P., Thomé C. Schädel-Hirn-Trauma [Traumatic brain injury]. Nervenarzt. 2023;94(10):960-972. https://doi.org/10.1007/s00115-023-01546-9
30. Ritter A. C., Wagner A. K., Fabio A., Pugh M. J., Walker W. [et al.]. Incidence and risk factors of posttraumatic seizures following traumatic brain injury: A Traumatic Brain Injury Model Systems Study. Epilepsia. 2016;57(12):1968-1977. https://doi.org/10.1111/epi.13582
31. Brown J. W., Lawn N. D., Lee J., Dunne J. W. When is it safe to return to driving following first-ever seizure? J. Neurol. Neurosurg. Psychiatry. 2015;86(1):60-64. https://doi.org/10.1136/jnnp-2013-307529
32. Chen Y., Li S., Ge W., Jing J., Chen H. Y. [et al.]. Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. J. Neurol. Neurosurg. Psychiatry. 2023;94(3):245-249. https://doi.org/10.1136/jnnp-2022-329542
33. Yu T., Liu X., Sun L., Wu J., Wang Q. Clinical characteristics of post-traumatic epilepsy and the factors affecting the latency of PTE. BMC Neurol. 2021;21(1):301. https://doi.org/10.1186/s12883-021-02273-x
34. Sharma S., Tiarks G., Haight J., Bassuk A. G. Neuropathophysiological mechanisms and treatment strategies for post-traumatic epilepsy. Front. Mol. Neurosci. 2021;14:612073. https://doi.org/10.3389/fnmol.2021.612073
35. Maslov N. E., Litvinova A. A., Kovalev P. S., Maslova N. N., Yuryeva N. V., Khamtsova E. I. Post-traumatic epilepsy: clinical, diagnostic and therapeutic features. Jepilepsija i paroksizmal’nye sostojanija. – Epilepsy and paroxysmal conditions. 2021;13(4):377-392. (In Russ.). https://doi.org/10.17749/2077-8333/epi.par.con.2021.100
36. Mariajoseph F. P., Chen Z., Sekhar P., Rewell S. S., O’Brien T. J. [et al.]. Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta-analysis. Epilepsia. 2022;63(11):2802-2812. https://doi.org/10.1111/epi.17398
7. Lobzin S. V., Vasilenko A. V. Post-traumatic epilepsy: clinical features and diagnosis. Jepilepsija i paroksizmal’nye sostojanija. – Epilepsy and paroxysmal conditions. 2014;6(3):70-76. (In Russ.).
38. Gudenschwager-Basso E. K., Shandra O., Volanth T., Patel D. C., Kelly C. [et al.]. Atypical neurogenesis, astrogliosis, and excessive hilar interneuron loss are associated with the development of post-traumatic epilepsy. Cells. 2023;12(9):1248. https://doi.org/10.3390/cells12091248
39. Chen L., Niu Q., Gao C., Du F. Celecoxib treatment alleviates cerebral injury in a rat model of post-traumatic epilepsy. Peer J. 2023;11:e16555. https://doi.org/10.7717/peerj.16555
40. Opeyemi O. M., Rogers M. B., Firek B. A., Janesko-Feldman K., Vagni V. [et al.]. Sustained dysbiosis and decreased fecal short-chain fatty acids after traumatic brain injury and impact on neurologic outcome. J. Neurotrauma. 2021;38(18):2610-2621. https://doi.org/10.1089/neu.2020.7506
41. You W., Zhu Y., Wei A., Du J., Wang Y. [et al.]. Traumatic brain injury induces gastrointestinal dysfunction and dysbiosis of gut microbiota accompanied by alterations of bile acid profile. J. Neurotrauma. 2022;39(1-2):227-237. https://doi.org/10.1089/neu.2020.7526
42. Hanscom M., Loane D. J., Shea-Donohue T. Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. J. Clin. Invest. 2021;131(12):e143777. https://doi.org/10.1172/JCI143777
43. Medel-Matus J. S., Lagishetty V., Santana-Gomez C., Shin D., Mowrey W. [et al.] Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile. Epilepsia. 2022;63(7):1835-1848. https://doi.org/10.1111/epi.17248
44. Olson C. A., Vuong H. E., Yano J. M., Liang Q. Y., Nusbaum D. J. [et al.]. The gut microbiota mediates the antiseizure effects of the ketogenic diet. Cell. 2018;174(2):497. https://doi.org/10.1016/j.cell.2018.06.051
45. Glukhova L. Yu., Mukhin K. Yu., Nikitina M. A., Barletova E. I., Tupikova E. A. The importance of electroencephalographic methods in the clinical practice of a neurologist. Russkij zhurnal detskoj nevrologii. – Russian Journal of Child Neurology. 2013;8(3):15-30. (In Russ.).
46. Belousova E. D. Genetics of epilepsy: why and how to examine children with epilepsy. Nevrologija, nejropsihiatrija, psihosomatika. – Neurology, neuropsychiatry, psychosomatics. 2014;6(1):4-8. (In Russ.).
47. Veldyaksova E. D., Yakunina A. V., Pisar A. A. Modern possibili-ties for personalized prescription of antiepileptic drugs. Zdorov’e i obrazovanie v XXI veke. – Health and education in the 21st century. 2017;19(4):56-61. (In Russ.).
48. Kalinin V. A., Poverennova I. E., Yakunina A. B., Beketova E. M. Innovative methods for diagnosing and treating epilepsy. Saratovskij nauchno-medicinskij zhurnal. – Saratov scientific and medical journal. 2017;3:144-149. (In Russ.).
49. Ramli N., Rahmat K., Lim K. S., Tan C. T. Neuroimaging in refractory epilepsy. Current practice and evolving trends. Eur. J. Radiol. 2015;84(9):1791-800. https://doi.org/10.1016/j.ejrad.2015.03.024
50. Ye T., Zhang J., Wang J., Lan S., Zeng T. [et al.]. Variants in BSN gene associated with epilepsy with favourable outcome. J. Med. Genet. 2023;60(8):776-783. https://doi.org/10.1136/jmg-2022-108865
51. Zhao G., Fu Y., Yang C., Yang X., Hu X. Exploring the pathogenesis linking traumatic brain injury and epilepsy via bioinformatic analyses. Front. Aging Neurosci. 2022;14:1047908. https://doi.org/10.3389/fnagi.2022.1047908
52. Sødal H. F., Storvig G., Tverdal C., Robinson H. S., Helseth E., Taubøll E. Early post-traumatic seizures in hospitalized patients with traumatic brain injury. Acta Neurol. Scand. 2022;146(5):485-491. https://doi.org/10.1111/ane.13670
53. Therajaran P., Hamilton J. A., O’Brien T. J., Jones N. C., Ali I. Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity. Epilepsia. 2020;61(2):203-215. https://doi.org/10.1111/epi.16424
54. Piccenna L., Shears G., O’Brien T. J. Management of posttraumatic epilepsy: An evidence review over the last 5 years and future directions. Epilepsia Open. 2017;2(2):123-144. https://doi.org/10.1002/epi4.12049
55. Maqbool A., Watt N. T., Haywood N., Viswambharan H., Skromna A. [et al.]. Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage. Am. J. Physiol. Cell. Physiol. 2020;319(1):C64-C74. https://doi.org/10.1152/ajpcell.00389.2019
Keywords: traumatic brain injury, post-traumatic epilepsy, diagnosis, treatment