• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2024.19063

Treating infected wounds with local negative pressure in diabetic foot syndrome cases

[Reviews]
Evgeny Pechenkin; Vladislav Vyacheslavovich Chudin; Ivan Polapin; Nikita Igorevich Kobylyatsky; Alexander Olegovich Nemchinov;

Vacuum as an option within comprehensive treatment for patients with long-term non-healing, purulent wound issues, has been used since the 1990s of the last century. The vacuum therapy procedure is technically simple. An important safety condition is thorough hemostasis during complete surgical treatment, removal of foreign bodies, as well as revision of nerves and blood vessels. The key to success in case of employing vacuum is periodic or constant negative pressure.

Frequent infectious complications in patients with diabetic foot syndrome are becoming more and more of a serious challenge faced by surgeons. Such issues are manifested via specific lesions affecting the patient’s legs, all this resulting from a complex set of morphofunctional changes. Given this, the method of vacuum therapy, treatment with local negative pressure, in view of the extensive range of its therapeutic effects in dealing with infectious complications of diabetic foot syndrome, is considered as highly effective, pathogenetically justified, and deserving active implementation and further study

Download

References:
1. Willy C., Agarwal A., Andersen C. A., Santis G., Gabriel A. [et al.]. Closed incision negative pressure therapy: international multidisciplinary consensus recommendations. Int. Wound. J. 2017;14(2):385-398. https://doi.org/10.1111/iwj.12612
2. Yadav S., Rawal G., Baxi M. Vacuum assisted closure technique: a short review. Pan. Afr. Med. J. 2017;28:246. https://doi.org/10.11604/pamj.2017.28.246.9606
3. Wang T., Li X., Fan L., Chen B., Liu J. [et al.]. Negative pressure wound therapy promoted wound healing by suppressing inflammation via down-regulating MAPK-JNK signaling pathway in diabetic foot patients. Diabetes Res. Clin. Pract. 2019;150:81-89. https://doi.org/10.1016/j.diabres.2019.02.024
4. Horch R. E. Incisional negative pressure wound therapy for high-risk wounds. J. Wound. Care. 2015;24(4):21-28. https://doi.org/10.12968/jowc.2015.24.Sup4b.21
5. Obolensky V. N. Modern methods of treatment of chronic wounds. Meditsinskii Sovet. – Medical Advice. 2016;10:148-154. (In Russ.). https://doi.org/10.21518/2079-701X-2016-10-148-154
6. Lee H. J., Jang Y. J. Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. Int. J. Mol. Sci. 2018;19(3):711. https://doi.org/10.3390/ijms19030711
7. Apelqvist J., Willy C., Fagerdahl A. M., Fraccalvieri M., Malmsjö M. [et al.]. EWMA Document: Negative Pressure Wound Therapy. J. Wound. Care. 2017;26(3):154. https://doi.org/10.12968/jowc.2017.26.Sup3.S1
8. Rasool A., Bashir S. A., Ahmad P. A., Bijli A. H., Baba U. F.[et al.]. Management of Wounds with Exposed Bones or Tendons in Children by Vacuum-Assisted Closure Therapy: A Prospective Study. Indian J. Plast. Surg. 2020;53(1):97-104. https://doi.org/10.1055/s-0039-3400192
9. Suzdaltsev I. V., Pechenkin E. V., Polapin I. A. Results and quality of life of patients with complicated forms of diabetic foot syndrome after complex treatment with exogenous nitrogen monoxide. Sovremennye problemy nauki i obrazovaniya. – Modern problems of science and education. 2016;2. Available at: www.science-education.ru/article/view?id=24415. Accessed April 27, 2016. (In Russ.).
10. Attia A., Elmenoufy T., Atta T., Harfoush A., Tarek S. Combination of negative pressure wound therapy (NPWT) and integra dermal regeneration template (IDRT) in the lower extremity wound; Our experience with 4 cases. JPRAS Open. 2020;24:32-39. https://doi.org/10.1016/j.jpra.2020.03.004
11. Sagy M., Singh J., Kalia A., Dahuja A., Garg S., Garg R. Wound healing of open fractures: comparison of vacuum assisted dressing versus traditonal dressing. Int. J. Orthop. Trauma. Nurs. 2020;36:100722. https://doi.org/10.1016/j.ijotn.2019.100722
12. Diehm Y. F., Loew J., Will P. A., Fischer S., Hundeshagen G. [et al.]. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) with V. A. C. VeraFlo in traumatic, surgical, and chronic wounds-A helpful tool for decontamination and to prepare successful reconstruction. Int. Wound. J. 2020;17(6):1740-1749. https://doi.org/10.1111/iwj.13462
13. Cherkasov M. F., Galashokyan K. M., Lukash A. I., Startsev U. M., Cherkasov D. M. [et al.]. Treatment of wounds of various etiologies using vacuum therapy. Sovremennye problemy nauki i obrazovaniya. – Modern problems of science and education. 2019;6:136. (In Russ.). https://doi.org/10.17513/spno.29337
14. Han S. K. Negative-Pressure Wound Therapy. In: Han S. K. editor. Inn. Ad. Wound Heal. 2016;183-200. https://doi.org/10.1007/978-3-662-46587-5_8
15. Anthony H. Efficiency and cost effectiveness of negative pressure wound therapy. Nurs. Stand. 2015;30(8):64-70. https://doi.org/10.7748/ns.30.8.64.s50
16. Razmakhnin E. V., Shangin V. A., Kudryavtseva O. G., Okhlopkov D. Y. Possibilities of vacuum instillation therapy using dimexide and betadine in the treatment of purulent wounds. Acta Biomedica Scientifica. 2017;2(6):153-156. (In Russ.). https://doi.org/10.12737/article_5a0a8e0d03dc42.56682733
17. Agarwal P., Kukrele R., Sharma D. Vacuum assisted closure (VAC)/negative pressure wound therapy (NPWT) for difficult wounds: A review. J. Clin. Orthop. Trauma.2019;10(5):845-848. https://doi.org/10.1016/j.jcot.2019.06.015
18. Datta S., Manoly I., Karangelis D., Hasan R. Pseudoaneurysm of right internal mammary artery post vacuum assisted closure therapy – a rare complication and literature review. Ann. Vasc. Surg. 2015;17:89-96. https://doi.org/10.1016/j.avsg.2015.08.010
19. Aycart M. A., Eble D. J., Ross K. M., Orgill D. P. Mechanisms of Action of Instillation and Dwell Negative Pressure Wound Therapy with Case Reports of Clinical Applications. Cureus. 2018;10(9):3377. https://doi.org/10.7759/cureus.3377
20. Bali Z. U., Akdeniz C. B., Müezzinoğlu T., Üçer O., Kara E. Comparison of Standard Open Wound Care and Vacuum-assisted Closure Therapy in Fournier’s Gangrene. J. Urol. Surg. 2020;7(1):42-45. https://doi.org/10.4274/jus.galenos.2019.3013
21. Bobkiewicz A., Banasiewicz T., Drews M. Postoperative pancreatic fistula successfully treated with «PEG-Like» endoscopic vacuum therapy. J. Laparoendosc. Adv. Surg. Tech. A. 2015;25(4):314-318. https://doi.org/10.1089/lap.2014.0463
22. D’Angelo F., Monestier L., Zagra L. Active septic arthritis of the hip in adults: what’s new in the treatment? A systematic review. EFORT Open. Rev. 2021;6(3):164-172. https://doi.org/10.1302/2058-5241.6.200082
23. Fedyushkin V. V., Baryshev A. G. Vacuum therapy in the treatment of wounds of various etiologies: a systematic review. Kubanskii nauchnyi meditsinskii vestnik. – Kuban Scientific Medical Bulletin. 2021;28(6):117-132. (In Russ.). https://doi.org/10.25207/1608-6228-2021-28-6-117-132
24. Dessy L. A., Serratore F., Corrias F., Parisi P., Mazzocchi M., Carlesimo B. Retention of polyurethane foam fragments during VAC therapy: a complication to be considered. Int. Wound J. 2015;12(2):132-136. https://doi.org/10.1111/iwj.12062
25. Shapovalov V. K., Basankin I. V., Afaunov A. A., Giulzatian A. A., Takhmazian K. K. [et al.]. The use of vacuum systems in early implant-associated infection that developed after decompression-stabilizing operations for lumbar spinal stenosis. Khirurgiya pozvonochnika. – Spinal surgery. 2021;18(3):53-60. (In Russ.). https://doi.org/10.14531/ss2021.3.53-60
26. El-Sabbagh A. H. Negative pressure wound therapy: An update. Chin. J. Traumatol. 2017;20(2):103-107. https://doi.org/10.1016/j.cjtee.2016.09.004
27. Everett E., Mathioudakis N. Update on management of diabetic foot ulcers. Ann. N. Y. Acad. Sci. 2018;1411:153-165. https://doi.org/10.1111/nyas.13569
28. Faschingbauer M., Boettner F., Bieger R., Weiner C., Reichel H., Kappe T. Outcome of Irrigation and Debridement after Failed Two-Stage Reimplantation for Periprosthetic Joint Infection. Biomed. Res. Int. 2018;2018:2875018. https://doi.org/10.1155/2018/2875018
29. Horch R. E., Beier J. P., Kneser U., Arkudas A. Successful human long-term application of in situ bone tissue engineering. J. Cell Mol. Med. 2014;18(7):1478-1485. https://doi.org/10.1111/jcmm.12296
30. Anagnostakos K., Mosser P. Bacteria identification on NPWT foams: clinical relevance or contamination. J. Wound Care. 2012;21(7):333-339. https://doi.org/10.12968/jowc.2012.21.7.333
31. Hämäläinen E., Laurikka J., Huhtala H., Järvinen O. Vacuum assistance therapy as compared to early reconstructive treatment in deep sternal wound infection. Scand. J. Surg. 2021;110(2):248-253. https://doi.org/10.1177/1457496920979289
32. Funari M. P., Coutinho Neto A. M., Farias G. F. A., de Moura E. G. H., Dos Santos M. E. L. Endoscopic vacuum therapy for postoperative GI fistula. VideoGIE. 2020;5(6):241-243. https://doi.org/10.1016/j.vgie.2020.03.001
33. Dedov I. I., Shestakova M. V., Vikulova O. K. State Register of diabetes mellitus in the Russian Federation: the status of 2015 and development prospects. Sakharnyi diabet. – Diabetes mellitus. 2015;3(18):5-22. (In Russ.). https://doi.org/10.14341/DM201535-22
34. Huang C., Leavitt T., Bayer L. R., Orgill D. P. Effect of negative pressure wound therapy on wound healing. Curr. Probl. Surg. 2014;51(7):301-331. https://doi.org/10.1067/j.cpsurg.2014.04.001
35. Hultman C. S. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. In: Hultman C. S., editor. 50 Studies Every Plastic Surgeon Should Know. CRC Press; 2014:331-336. https://doi.org/10.1201/b17524-51
36. Kordestani S. S. Wound Healing Process. In: Atlas of Wound Healing. Elsevier. 2019:11-22. https://doi.org/10.1016/b978-0-323-67968-8.00003-3
37. Krpata D. M. Wound Closure and Management. Surg. Infect. (Larchmt). 2019; 20(2):135-138. https://doi.org/10.1089/sur.2018.235
38. Pyatakov S. N., Porkhanov V. A., Bensman V. M., Baryshev A. G.,Pyatakova S. N., Butenko D. V. Study of the clinical efficacy of the method of metered tissue destruction in the treatment of soft tissue defects of various etiologies in the lower extremities. Innovatsionnaya meditsina Kubani. – Innovative medicine of Kuban. 2019;2:36-44. (In Russ.). https://doi.org/10.35401/2500-0268-2019-14-2-36-44
39. Li T., Wang G., Yin P., Li Z., Zhang L., Tang P. Adaptive expression of biofilm regulators and adhesion factors of Staphylococcus aureus during acute wound infection under the treatment of negative pressure wound therapy in vivo. Exp. Ther. Med. 2020;20(1):512-520. https://doi.org/10.3892/etm.2020.8679
40. Malathi L., Das S., Nair J. T. K., Rajappan A. Chest wall reconstruction: success of a team approach-a 12-year experience from a tertiary care institution. Indian J. Thorac. Cardiovasc. Surg. 2020;36(1):44-51. https://doi.org/10.1007/s12055-019-00841-y
41. Mazoch M., Montgomery C. Retained wound vacuum foam in non-healing wounds: a real possibility. J. Wound Care. 2015;24(6):18-20. https://doi.org/10.12968/jowc.2015.24.Sup6.S18
42. Nisi F., Marturano F., Natali E., Galzerano A., Ricci P., Peduto V. A. VAC therapy with long term continuous saline infusion for secondary septic peritonitis: A new strategy for the reduction of perioperative risks? Int. J. Surg. Case. Rep. 2017;32:62-65. https://doi.org/10.1016/j.ijscr.2017.02.010
43. Miyahara H. S., Serzedello F. R., Ejnisman L., Lima A. L. L. M.,Vicente J. R. N., Helito C. P. Incisional negative-pressure wound therapy in revision total hip arthroplasty due to inection. Acta. Ortop. Bras. 2018;26(5):300-304. https://doi.org/10.1590/1413-785220182605196038
44. Müller V., Piper S. K., Pratschke J., Raue W. Intraabdominal continuous negative pressure therapy for secondary peritonitis: an observational trial in a maximum care center. Acta. Chir. Belg. 2020;120(3):179-185. https://doi.org/10.1080/00015458.2019.1576448
45. Nakade D. D. V., Zade D. M., Mehta D. J., Gupta D. S., Pandita D. A. Role of vacuum assisted closure (VAC) in treatment of difficult to heal wounds in lower extremityour experience in 100 cases. International J. Surg. Sci. 2020;4(1):445-450. https://doi.org/10.33545/surgery.2020.v4.i1h.383
46. Mintziras I., Miligkos M., Bartsch D. K. High risk of fistula formation in vacuum-assisted closure therapy in patients with open abdomen due to secondary peritonitis – a retrospective analysis. Langenbecks Arch. Surg. 2016;401(5):619-625. https://doi.org/10.1007/s00423-016-1443-y
47. Suzdaltsev I. V., Polapin I. A. Complex treatment of ulcerative necrotic lesions in diabetic foot syndrome. Stavropol, 2018. (In Russ.).
48. Pesonen L. O., Halloran B. G., Aziz A. Prophylactic Groin Wound Vacuum-assisted Therapy in Vascular Surgery Patients at Enhanced Risk for Postoperative Wound Infection. Ann. Vasc. Surg. 2018;46:127-133. https://doi.org/10.1016/j.avsg.2017.07.009
49. Potula V. S. Conventional treatment versus vacuum therapy for diabetic foot ulcers treatment. Int. Surg. J. 2017;5(1):49. https://doi.org/10.18203/2349-2902.isj20175482
50. Shavit E., Pawliwec A., Alavi A., George R. The surgeon’s perspective: a retrospective study of wide local excisions taken to healthy subcutaneous fat in the management of advanced hidradenitis suppurativa. Can. J. Surg.2020;63(2):94-99. https://doi.org/10.1503/cjs.003119
51. Fedyanin S. D. The effect of the combined use of septomyrin and chlorhexidine on the bacterial contamination of purulent wounds. Problemy zdorov’ya i ehkologii. – Health and environmental issues.2021;18(1):35-40. (In Russ.). https://doi.org/10.51523/2708-6011.2021-18-1-5
52. Scalise A., Calamita R., Tartaglione C., Pierangeli M., Bolletta E. [et al.]. Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of Incisional Negative Pressure Wound The rapy. A systematic review of the literature. Int. Wound J.2016;13(6):1260-1281. https://doi.org/10.1111/iwj.12492
53. Shah P. D. O. P. Low Cost Innovative Modification of Vacuum Assisted Wound Therapy. J. Med. Sci. Clin. Res. 2018;6(2):161. https://doi.org/10.18535/jmscr/v6i2.161
54. Singh D., Chopra K., Sabino J., Brown E. Practical Things You Should Know about Wound Healing and Vacuum-Assisted Closure Management. Plast. Rec. Surg. 2020;145(4):839-854. https://doi.org/10.1097/prs.0000000000006652
55. Vaccaro A. R., Rothman R. H., Albert T. J. Disorders of the skin and soft tissues. In: Essential Surgical Practice. CRC Press. 2015;361-388. https://doi.org/10.1201/b17820-21
56. Dedov I. I., Shestakova M. V., Galstyan G. R., Grigoryan O. R., Esayan R. M. [et al.]. Algorithms of specialized medical care for patients with diabetes mellitus. Sakharnyi diabet. – Diabetes mellitus. 2015;1S(18):111-112. (In Russ.). https://doi.org/10.14341/DM20151S
57. Webster J., Scuffham P., Stankiewicz M., Chaboyer W. P. Negative pressure wound therapy for skin grafts and surgical wounds healing by primary intention. Coch. Datab. Syst. Rev. 2014;10:CD009261. https://doi.org/10.1002/14651858.CD009261.pub3
58. Vinnik Yu. S., Markelova N. M., Solovyova N. S., Shishatskaia E. I., Kuznetsov M. N. [et al.]. Modern wound coatings in the treatment of purulent wounds. Novosti khirurgii. – Surgery news.2015;5(23):552-558. (In Russ.).
59. Wolvos T. The evolution of negative pressure wound therapy: negative pressure wound therapy with instillation. J. Wound Care. 2015;24(4):15-20. https://doi.org/10.12968/jowc.2015.24.Sup4b.15
60. Gafiullov M. R., Suvorova S. A., Gorelkin V. I., Orelkina Yu. D. Application of a vacuum aspiration system for the treatment of purulent wounds of the anterior abdominal wall after complicated abdominoplasty. Wounds and wound infections. Zhurnal im. prof. B. M. Kostyuchenka. – The journal named after prof. B. M. Kostyuchenka. 2019;6(3):44-49. (In Russ.). https://doi.org/10.25199/2408-9613-2019-6-3-44-49

Keywords: diabetic foot syndrome, wound infection, local negative pressure