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https://doi.org/10.14300/mnnc.2024.19044

Bone metabolism status in children with chronic respiratory diseases

[Reviews]
Svetlana Dolbnya; Viktoriya Romanovna Ponamareva; Irina Zakharova; Leonid Klimov; Anna Aleksandrovna Tolkunova; Natalya Zarytovskaya; Vladislav Denisovich Lugovsky; Darya Alekseevna Pentegova;

This review focuses on the specific issues of bone metabolism in children with chronic respiratory diseases, namely, cystic fibrosis and bronchial asthma. The results of numerous studies show that patients with chronic bronchial and lung issues tend to develop a premature imbalance of bone remodeling, the clinical manifestations of which include osteopenia, osteoporosis and low-impact fractures. There is also a discussion offered around factors that have a certain effect on the bone metabolism status at the physiological level, as well as around the role of various pathogenetic mechanisms and medication therapy in affecting bone mineral density in pediatric patients suffering from cystic fibrosis and bronchial asthma.

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Keywords: cystic fibrosis, bronchial asthma, osteopenia, osteoporosis, bone metabolism