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https://doi.org/10.14300/mnnc.2024.19007

Level of antimicrobial peptides in children with urinary tract infection

[Pediatrics]
Anna Nikolaevna Tsutsaeva; Leonid Klimov; Artem Kamoevich Minasyan; Svetlana Dolbnya; Anna Ilyinichna Beketova; Vladislav Ramazanovich Taglanov; Lev Borisovich Pantelov; Natalya Zarytovskaya;

This article is presented the result of the activity study of innate immunity factors in children with urinary tract infection (n=75) in comparison with healthy children in the control group (n=30). Laboratory examination included determination of serum concentrations of antimicrobial peptides – cathelicidin (LL-37), β1-defensin and β2-defensin. The levels of antimicrobial peptides were statistically significantly higher in the group of patients with UTI compared to the control group (p=0.003; p=0.007; p=0.007, respectively).

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Keywords: urinary tract infection, children, innate immunity, antimicrobial peptides, cathelicidin, defensins