• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2023.18097

«Inflammatory index» and histological features in non-alcoholic fatty liver disease

[Abstracts]
Yuliya Alexandrovna  Kravchenko; Pavel Koroy;

In 40 patients with non-alcoholic fatty liver disease (NAFLD), the relationship of «inflammatory index» with the morphological manifestations of the disease was studied. The «inflammatory index» (in points) was the number of five markers of inflammation (E, P, L-selectins, ESR, C-reactive protein) with values above 95 % of the confidence interval of the average in the healthy group. The frequency of severe liver fibrosis reached 66.7 % in patients with values of «inflammatory index» of 5 points. The parameters of the «inflammatory index» in severe fibrosis (3 (2; 4) points) were higher than in less pronounced liver fibrosis (2 (2; 3) points, p = 0.003). The risk of severe fibrosis increases in patients with values of «inflammatory index» of ≥4 points (OR 8.33 (95 % CI 1.60–43.29), p<0.05). The accuracy of the index in predicting of severe fibrosis was 77.5 %.

Download

References:
1. Berardo C., Di Pasqua L. G., Cagna M., Richelmi P., Vairetti M. [et al.]. Nonalcoholic fatty liver disease and non-alcoholic steatohepatitis: current issues and future perspectives in preclinical and clinical research. Int. J. Mol. Sci. 2020;21(24):9646. https://doi.org/10.3390/ijms21249646
2. Hammoutene A., Rautou P. E. Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease. J. Hepatol. 2019;70(6):278-1291. https://doi.org/10.1016/j.jhep.2019.02.012
3. Drescher H. K., Schippers A., Rosenhain S., Gremse F., Bongiovanni L. [et al.]. L-Selectin/CD62L is a key driver of non-alcoholic steatohepatitis in mice and men. Cells. 2020;9:1106. https://doi.org/10.3390/cells9051106
4. Matsumoto M., Zhang J., Zhang X., Liu J., Jiang J. X. [et al.]. The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radical. Biol. Med. 2018;115:412-420. https://doi.org/10.1016/j.freeradbiomed.2017.12.019
5. Yagoda A. V., Koroy P. V., Slyadnev S. A. Positive correlation of the level of molecules of superfamily immunoglobulins ICAM-1, VCAM-1 and PECAM-1 with the index of fibroi Klinicheskaya Gastroenterologiya. – Experimental and Clinical Gastroenterology. 2017;138(2):45-51. (In Russ.).
6. Ajmera V., Perito E. R., Bass N. M., Terrault N. A., Yates K. P. [et al.]. Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. Hepatology. 2017;65(1):65-77. https://doi.org/10.1002/hep.28776

Keywords: nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, liver fibrosis, selectins, «inflammatory index»