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https://doi.org/10.14300/mnnc.2023.18087

Genetic polymorphisms and neurological outcomes of hypoxic-ischemic encephalopathy

[Neurology]
Ekaterina Sergeevna Salnikova; Lyudmila Barycheva; Oleg Agranovich; Vera Valentinovna Kuznetsova; Natalia Alexandrovna Kozmova;

Expression of IL-1β and TNF-α is a key event in hypoxic-ischemic injury and secondary brain injury in the newborn. Cytokine gene polymorphisms may influence the consequences of residual outcomes of hypoxic-ischemic encephalopathy. A study of polymorphic markers IL-1β C(–31)T (rs1143627) and TNF-α G308A (rs1800629) was carried out in 96 newborns using PCR with identification of restriction fragment lengths. A connection has been established between the polymorphism of the IL-1β and TNF-α genes and the development of hypoxic-ischemic encephalopathy. The formation of unfavorable neurological outcomes occurs predominantly in residents of the IL-1β (–31)Т, TNF-α 308 A alleles and IL-1β (–31)T/T, TNF-α 308 A/A genotypes. High expression of IL-1β is observed in residents of the IL-1β (–31) T allele and the IL-1β (–31) T/T genotype, TNF-α – allele 308 A.

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Keywords: hypoxic-ischemic encephalopathy, neurological outcomes, IL-1β, TNF-α, polymorphism