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https://doi.org/10.14300/mnnc.2023.18079

Microbiota – gut – brain communication system: the role of neurotransmitters and neuropeptides

[Reviews]
Marina Samotrueva; Olga Bashkina; Alexandra Aleksandrovna Tsibizova;

The human gut microbiota, representing a unique set of metabolically active microorganisms, plays an important role in the regulation of a wide range of physiological processes, including the functioning of the neuroimmunoendocrine system through neuronal, immune and metabolic interactions, which play a role in the pathogenesis of neurodegenerative processes. Numerous studies indicate the homeostatic role of the intestinal microbiota due to the production of biologically active molecules (neuropeptides, neurotransmitters, bacteriocins, neurotrophic factors, etc.), which exhibit neuroactive, immunomodulatory, metabolic and antimicrobial properties at the local and systemic levels, which actualizes the study of them as promising therapeutic agents.

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Keywords: gut microbiota, neuropeptides, neurotransmitters, bacteriocins, antimicrobial peptides, neurotrophic factors, neuronal interactions