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https://doi.org/10.14300/mnnc.2023.18023

Modern view on pathogenetic mechanisms of age-related skin changes

[Reviews]
Nikolay Nikolaevich Potekaev; Olga Borisovna Borzykh; Elena Ivanovna Karpova; Marina Mikhailovna Petrova; Natalia Alekseevna Schneider; Olga Mikhailovna Demina; Maria Alekseevna Zatolokina;

Aging is a genetically determined, inevitable process of reducing the functional activity of all organs and tissues. Skin aging is of particular interest since the skin is the largest visible human organ and the earliest manifestations of aging can be noted on the skin. Also, the skin is a protective border for all internal organs and tissues, therefore, on the one hand, it is more influenced by external factors, on the other hand, a decrease in its protective properties during aging can affect the underlying organs. In aesthetic cosmetology, most often we are faced with the need of patients to restore the lost function of shape maintaining (which causes wrinkles and a decrease in skin elasticity). At the same time, a large number of aesthetic medicine techniques are aimed at increasing the rigidity of the dermis, due to the formation of fibrosis. The review provides arguments in favor of the need to revise tactics that only contribute to strengthening the skin and the formation of fibrosis.

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Keywords: skin aging, internal aging, external aging, involutional changes in the extracellular matrix of the skin