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EBSCO

https://doi.org/10.14300/mnnc.2022.17111

E-cadherin and the gingival epithelial barrier

[Reviews]
Ekaterina Mikhailovna Speranskaya; Natalia Nikolaevna Golubtsova; Lyubov Rustemovna Mukhamedzhanova; Evgeny Vasilyevich Moskvichev;

The analytical review highlights the issues of the structure of the gingival epithelium, intercellular contacts of epithelial cells, as well as the effect of a complex of exogenous and endogenous factors on the expression of the marker of intercellular adhesion (E-cadherin). A decrease in the expression of the E-cadherin molecule leads to inhibition of the gingival epithelial barrier and to the development of inflammatory and destructive periodontal diseases, which determines the importance of studying the effect of exogenous and endogenous factors on changes in the intercellular contacts of epithelial cells.

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Keywords: E-cadherin, gum epithelial cells, intercellular contacts, TNF-α, Porphyromonas gingivalis, vitamin D, antioxidants